Development of methods to prevent alveolar bone absorption during periodontitis using epigenetic regulation

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In this study, we examined a hypothesis that modulation of histone acetylation or methylation may also have some effect on the osteoclast differentiation. RANKL treatment induced the number of multinucleated osteoclast-like cells and the TRAP activities. Both histone deacetylase and methyltransferase inhibiton decreased the number of RANKL-induced osteoclast-like cells and TRAP activities in a dose-dependent manner. During the experiments, we also observed that RANKL treatment induced Raw264.7 cell death and the histone-deacetylase or histone methyltransferase-inhibitor dose-dependently suppressed the RANKL-induced cell death.