Effects of ethanol on methamphetamine-induced dopamine release in high and low alcohol preference rats.

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Changes in dopamine and serotonin release induced by MAP (1 mg/kg, intraperitoneally) after pretreatment with D1 and D2 receptor antagonists were examined in the striatum of rats with different alcohol preferences to elucidate differences in receptor levels between the two rat strains. With haloperidol treatment both strains rats showed a significantly greater maximum increase on MAP-induced dopamine release compared with respective control rats. However, after SCH23390 treatment only HAP rats showed a significantly greater increase in dopamine release compared with controls. These data suggested that alcohol preference is associated with the action of MAP, and the dopaminergic mechanism, specifically the D1 system in the striatum, might have a different pathway dependent on alcohol preference.