Development of intelligent-type drug delivery system by transporter protein.
Development of intelligent-type drug delivery system by transporter protein.
批准号:
21200076
负责人:
INUI Takashi
金额:
$16.89万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们构建了NGR(Asn-Gly-Arg)-lipocalin-type prostaglandin D synthase(L-PGDS),具有肿瘤靶向性NGR基序,能特异性结合血管内皮细胞表达的CD 13受体。NGR-L-PGDS与水溶性差的抗肿瘤药物SN-38复合。与在PBS中的溶解度相比,在PBS中存在2 mM NGR-L-PGDS的情况下SN-38的溶解度增加了300倍。在使用人结肠癌细胞的小鼠异种移植肿瘤模型中,与对照相比,SN-38/NGR-L-PGDS复合物静脉给药显著抑制肿瘤生长。
英文摘要
We generated NGR (Asn-Gly-Arg)-lipocalin-type prostaglandin D synthase (L-PGDS), possessing tumor-targeting NGR-motif, which specifically binds to CD13 receptor expressing in the endothelium of angiogenic blood vessels. NGR-L-PGDS was complexed with SN-38 which is a poorly water-soluble antitumor drug. The solubility of SN-38 in the presence of 2 mM NGR-L-PGDS in PBS increased by 300-fold as compared with that in PBS. Intravenous administration of SN-38/NGR-L-PGDS complex dominantly inhibited tumor growth as compared with control in mouse xenograft tumor model using human colon cancer cells.
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樹状高分子を利用した新規擬似ペプチドの設計
使用树枝状聚合物设计新的伪肽
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[児島千恵, 他]
通讯作者:
他
Thermodynamics of Human Lipocalin-type Prostaglandin D Synthase and Lipophilic Ligand Interaction
人脂质运载蛋白型前列腺素 D 合酶与亲脂性配体相互作用的热力学
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Satoshi Kume, 他]
通讯作者:
他
Thermal stability and unfolding mechanism of human lipocalin-type prostaglandin D synthase.
人脂质运载蛋白型前列腺素D合酶的热稳定性和解折叠机制。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kaoru Saruwatari, 他]
通讯作者:
他
変異型リポカリン型プロスタグランジンD合成酵素とdiazepamとの結合親和性と薬効の関係
突变型脂质运载蛋白型前列腺素D合酶与地西泮的结合亲和力与药效关系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[宮志遠, 他]
通讯作者:
他
Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR.
通过小角 X 射线散射和多维 NMR 分析与胆绿素复合的脂质运载蛋白型前列腺素 D 合酶的结构。
DOI:
--
发表时间:
2010
期刊:
J. Struct. Biol.
影响因子:
--
作者:
[Miyamoto, Y., Nishimura, S., Inoue, K., Shimamoto, S., Yoshida, T., Fukuhara, A., Yamada, M., Urade, Y., Yagi, N., Ohkubo, T., and Inui, T. (correspondence author)]
通讯作者:
T. (correspondence author)
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A Study on Automatic Indexing Based on Textual Mentions to Geographical Location in Story Archiving
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批准号:18K11982
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资助金额:$2.75万
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财政年份:2018
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负责人:INUI Takashi
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依托单位:
A Study of Detecting "bad mouth" Comments in Social Media based on Actual Usage of Language Expressions
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批准号:15K20884
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资助金额:$2.58万
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财政年份:2015
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负责人:INUI Takashi
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Design of tailor-made micro-carrier protein having molecular-selective recognition.
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批准号:17300165
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2005
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负责人:INUI Takashi
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依托单位: