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Genetic studies on unique phenotypes in MSM/Ms mouse strain

Genetic studies on unique phenotypes in MSM/Ms mouse strain
MSM/Ms 小鼠品系独特表型的遗传研究
批准号:
21220010
负责人:
YAMAMURA Ken-ichi
金额:
$134.78万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009-05-11 至 2014-03-31

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中文摘要
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英文摘要
In MSM/Ms mouse, we showed that coordinate function of thalamus, midbrain, pons, and medulla was essential for its agility. In addition, high induction of Spink3 was involved in resistance to cerulein-induced pancreatitis. Furthermore, we succeeded to create knock out and knock-in mice in MODY associated genes including HNF1alpha, HNF1beta, HNF4alpha, Pdx1, NeuroD, Gck, that become valuable resources in research community.
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典型的な優性遺伝病の発症における環境要因
典型显性遗传病发生过程中的环境因素
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Koji Hayakawa, Mitsuko Hirosawa, Satoshi Tanaka, Shintaro Yagi, Kunio Shiota, 山村研一]
通讯作者: 山村研一
The Roles of Serine Protease Inhibitor Kazal Type 1 (SPINK1) in Pancreatic Diseases
丝氨酸蛋白酶抑制剂 Kazal 1 型 (SPINK1) 在胰腺疾病中的作用
DOI: 10.1538/expanim.60.433
发表时间: 2011
期刊: Experimental Animals
影响因子: 2.4
作者: [Ohmuraya M., et al]
通讯作者: et al
Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression
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DOI: 10.1038/labinvest.2010.44
发表时间: 2010
期刊: Lab. Invest
影响因子: --
作者: [Wang, J., Ohmuraya, M., Suyama, K., Hirota, M., Ozaki, N., Baba, H., Nakagata, N., Araki, K. and Yamamura, K]
通讯作者: K
EGTCマウスラインのKEGGパスウェイ解析
EGTC小鼠系的KEGG通路分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [荒木正健、吉信公美子, 他4名]
通讯作者: 他4名
72
    Identification of genes responsible for developmental mutant mice
    • 批准号:
      09044325
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $4.16万
    • 财政年份:
      1997
    • 负责人:
      YAMAMURA Ken-ichi
    • 依托单位:
    IDENTIFICATION OF DEVELOPMENTAL CONTROL GENES USING YAC TRANSGENIC MICE
    • 批准号:
      07044282
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $3.2万
    • 财政年份:
      1995
    • 负责人:
      YAMAMURA Ken-ichi
    • 依托单位:
    Production of mouse models for human diseases by gene targeting
    Analysis on the molecular mechanism of development using insertional mutant mice.
    • 批准号:
      01044117
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $4.22万
    • 财政年份:
      1989
    • 负责人:
      YAMAMURA Ken-ichi
    • 依托单位:
    海外基金