Investigation for the mechanism of joint contracture and the effect of rehabilitation based on comprehensive analysis concerning surrounding tissue of joint

点击翻译按钮获取中文摘要

Clinically, the contracture that is one of the functional disorders is often caused by immobilization of a joint with a plastic cast etc, however, this mechanism is not yet clear. The objective of this study is to clarify the mechanism of contracture based on comprehensive analysis concerning surrounding tissue of joint in experimental animal model. Our results suggest that the molecular mechanism of immobilization-induced muscle fibrosis relate the cytokine signal by TGF-βis activated, the differentiation from the fibroblast to myofibroblast is accelerated, and the type I and III collagen increase. Additionally, the immobilization-induced muscle fibrosis may progress by a decrease in mechanical stimulation. Immobilization of the joint causes the fibrosis of the synovial membrane and the tissue under the skin. There is an important relation in the mechanism because the contracture progresses by these changes.