Biological effects of therapeutic exercise on osteoarthritis of kneeand developmental study of biomarker
治疗运动对膝骨关节炎的生物学效应及生物标志物发育研究
基本信息
- 批准号:22650130
- 负责人:
- 金额:$ 2.12万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of this study is to present the basic data for biological effects of therapeutic exercise on osteoarthritis of knee. We simulated two kinds of therapeutic exercises like continuous passive motion and low-intensity exercise by neuromuscular electrical stimulation, and examined the effects of therapeutic exercisesduring the early stages of arthritis on inflammation and pain-related behavior in rat’sarthritis model. As a result, therapeutic exercises significantly accelerated the amelioration of joint swelling and pressure withdrawal threshold and increased the mechanical withdrawal threshold immediately after treatment. We hypothesized that the mechanism of such a biological effect by therapeutic exercise related to the up-regulation of anti-inflammatory cytokine on surrounding tissue of joint. Additionally, we assumed that anti-inflammatory cytokine was able to use as the biomarker.
本研究的目的是提供治疗性运动对膝关节骨性关节炎生物学效应的基础数据。本研究采用神经肌肉电刺激模拟关节炎早期持续被动运动和低强度运动两种治疗性运动,观察关节炎早期治疗性运动对大鼠关节炎模型炎症和疼痛相关行为的影响。结果,治疗性运动显著加速了关节肿胀和压力撤回阈值的改善,并在治疗后立即提高了机械撤回阈值。我们推测治疗性运动的这种生物学效应的机制与关节周围组织中抗炎细胞因子的上调有关。此外,我们假设抗炎细胞因子能够用作生物标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
人工股関節全置換術前後の痛みの発生状況がT字杖歩行自立日数におよぼす影響
全髋关节置换术前后疼痛发生情况对T型手杖独立行走天数的影响
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Kawamata;S.;Kurose;T.;石井瞬,下迫淳平,坂本淳哉,森本陽介,上原ひろの,山下正太郎,神津玲,尾崎誠,松坂誠應,沖田実
- 通讯作者:石井瞬,下迫淳平,坂本淳哉,森本陽介,上原ひろの,山下正太郎,神津玲,尾崎誠,松坂誠應,沖田実
Investigation of Pain in Hip Disease Patients before and after Arthroplasty
- DOI:10.1589/jpts.23.535
- 发表时间:2011-06-01
- 期刊:
- 影响因子:0
- 作者:Morimoto, Yosuke;Kondo, Yasutaka;Okita, Minoru
- 通讯作者:Okita, Minoru
大腿骨近位部骨折術後の痛みの発生状況に関する調査
股骨近端骨折术后疼痛发生情况调查
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:片岡英樹;西川正吾;渋谷美帆子;岩佐恭平;山口紗智;村上正寛;中川勇樹;吉田奈央;鵜殿紀子;濱崎忍;三村国秀;山下潤一郎;坂本淳哉;中野治郎;沖田実
- 通讯作者:沖田実
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OKITA Minoru其他文献
OKITA Minoru的其他文献
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{{ truncateString('OKITA Minoru', 18)}}的其他基金
Development of the physiotherapeutic strategy for muscle fibrosis with HIF-1 alpha as a therapeutic target
以 HIF-1 α 作为治疗靶点的肌肉纤维化物理治疗策略的开发
- 批准号:
16K12937 - 财政年份:2016
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Experimental study on elucidation of target molecule of joint contracture and development of therapeutic strategy for new physical therapy
关节挛缩靶分子阐明及新型物理疗法治疗策略开发的实验研究
- 批准号:
15H03045 - 财政年份:2015
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Investigation for the mechanism of hypoalgesia after upper limbs exercise for postoperative patients with lower extremity arthritis
下肢关节炎术后患者上肢运动后痛觉减退的机制探讨
- 批准号:
25560263 - 财政年份:2013
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Investigation for the biological effects of physical therapy in tissue injury-induced chronic pain and immobilization-induced chronic pain
物理治疗对组织损伤引起的慢性疼痛和制动引起的慢性疼痛的生物学效应的研究
- 批准号:
24300193 - 财政年份:2012
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Investigation for the mechanism of joint contracture and the effect of rehabilitation based on comprehensive analysis concerning surrounding tissue of joint
基于关节周围组织综合分析探讨关节挛缩机制及康复效果
- 批准号:
21300200 - 财政年份:2009
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Experimental study for the mechanism of muscle contracture and the effect of therapeutic exercise and electrophysical agents
肌肉挛缩机制及治疗运动和电物理制剂效果的实验研究
- 批准号:
18500428 - 财政年份:2006
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The experimental study for the explication of mechanism and therapy on the joint contracture
关节挛缩机制及治疗阐明的实验研究
- 批准号:
12832036 - 财政年份:2000
- 资助金额:
$ 2.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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