Biological effects of therapeutic exercise on osteoarthritis of kneeand developmental study of biomarker

本研究的目的是提供治疗性运动对膝关节骨性关节炎生物学效应的基础资料。通过神经肌肉电刺激模拟连续被动运动和低强度运动两种治疗性运动，观察关节炎早期治疗性运动对大鼠关节炎模型炎症和疼痛相关行为的影响。结果，治疗性运动显著加速了关节肿胀和压力戒断阈值的改善，并在治疗后立即增加了机械戒断阈值。我们假设治疗性运动产生这种生物学效应的机制与关节周围组织抗炎细胞因子的上调有关。此外，我们假设抗炎细胞因子能够作为生物标志物。

The objective of this study is to present the basic data for biological effects of therapeutic exercise on osteoarthritis of knee. We simulated two kinds of therapeutic exercises like continuous passive motion and low-intensity exercise by neuromuscular electrical stimulation, and examined the effects of therapeutic exercisesduring the early stages of arthritis on inflammation and pain-related behavior in rat’sarthritis model. As a result, therapeutic exercises significantly accelerated the amelioration of joint swelling and pressure withdrawal threshold and increased the mechanical withdrawal threshold immediately after treatment. We hypothesized that the mechanism of such a biological effect by therapeutic exercise related to the up-regulation of anti-inflammatory cytokine on surrounding tissue of joint. Additionally, we assumed that anti-inflammatory cytokine was able to use as the biomarker.