Experimental rehabilitation on rodents hemiplegia

我们利用啮齿动物偏瘫模型对各种实验性康复进行了研究。X射线分析提供了关于动物运动/行为及其对关节-骨骼系统的调节的更重要的详细信息。痛觉是反映偏瘫康复过程的良好指标，以期探索一种可靠的康复模式。我们首次成功地对控制啮齿动物行为/运动的中枢神经系统的电生理和神经化学活动进行了双重测量。这些大脑区域对机械加载和卸载有积极和消极的反应。适当的机械负荷提高了海马区和杏仁核突触传递的效率，反映了学习/记忆和情绪反应的刺激功能。这些基于分子的方法将有助于偏瘫的新康复。

We studied on various experimental rehabilitation using rodent hemiplegia models. X-ray analysis provides more significant detailed information about moving/behavior and its regulation on the joint-skeletal system of animals. Pain sensation makes a good indicator that reflects the recovery process of hemiplegia so as to prospect a reliable rehabilitation model. We succeeded for the first time in dual measurement of electrophysiological and neurochemical activities of the CNS that controls behavior/moving of rodents. These brain areas respond positively and negatively to mechanical loading and unloading. An appropriate mechanical loading enhances efficiency of synaptic transmission in hippocampus and amygdala that reflects stimulated function of learning/memory and emotional response. These molecular-based approaches would contribute to new rehabilitation for hemiplegia.