Development of a blood flow observation system under loading the shear force and its analysis for pressure ulcers

在本研究中，我们分析了压疮的发病机制，作为建立压疮预防的基础技术和开发有效的设备的初步研究。我们从宏观和微观生物医学方法的角度对其进行探讨。从宏观上看，我们开发了一种作用于活体的装置，可以量化和控制压力和剪切力，这被认为是压疮的主要因素，并测量了压力作用于人体时的经皮氧分压。并建立了能够模拟人体负荷的仿真模型。从微观上看，我们研制了一种可以施加可控压力和剪切力的血流观察仪。它可以通过一个华丽的电子相机直接观察红细胞的流动。

In this study, we analyze the mechanism of pressure ulcers as primary study for establishing basis techniques and for developing effective devices for pressure ulcers prevention. We approach it from the view of macro and micro biomedical method. From the macro view, we developed a device that acts on a living body with quantified and controlled pressure and shear force that are considered to be the main factors for pressure ulcers and measured the transcutaneous oxygen tension when the force is applied tohuman body. And also, we established a simulation model which can simulate the load for human body. From the micro view, we developed a blood flow observation device which can apply the controlled pressure and shear force. It can watch the flow of red cell directly by a magnificent electric camera.