Systemic factors responsible for cross-transfer effect of muscle hypertrophy after resistance exercise training

抗阻运动训练后肌肉肥大交叉转移效应的全身因素

• 批准号: 21300235
• 负责人: ISHII Naokata
• 金额: $ 11.23万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300235/
• 关键词: レジスタンストレーニング; 筋肥大; 効果転移; 循環因子; プロテオーム解析; 培養筋芽細胞; シグナル伝達系; 運動・トレーニング; プオテオーム解析; 培養筋細胞; タンパク質合成; ショットガン解析; 血流制限

A low-intensity resistance training for upper arm muscles, if ineffective for muscle hypertrophy, can cause muscle hypertrophy when combined with a resistance training with vascular occlusion for thigh muscles("cross-transfer" of muscle hypertrophy ; Madarame et al., 2008). The present study investigated the role played by systemic factors in this cross-transfer effect. Training experiments with humans showed that conventional, high-intensity resistance training can also cause the similar cross-transfer effect. In addition, proteomic analysis of serum samples taken before and after the training with vascular occlusion showed significant changes in the concentration of several growth factors. When serum was taken from rats subjected to high-intensity resistance training and then added to cultured myoblasts, it caused significant changes in signal transduction substrates related to protein synthesis. These results suggest that some growth factors within serum play important parts in the cross-transfer effect of muscle hypertrophy.

上臂肌肉的低强度阻力训练如果对肌肉肥大无效，则当与大腿肌肉的血管闭塞阻力训练相结合时可能导致肌肉肥大（肌肉肥大的“交叉转移”; Madarame等人，2008年）。本研究探讨了系统因素在这种交叉迁移效应中所起的作用。人体训练实验表明，常规的高强度抗阻训练也能引起类似的交叉迁移效应。此外，蛋白质组学分析之前和之后采取的血清样本与血管闭塞的训练显示显着变化的几个生长因子的浓度。当从接受高强度阻力训练的大鼠中提取血清，然后加入培养的成肌细胞中时，它引起了与蛋白质合成相关的信号转导底物的显着变化。提示血清中某些生长因子在肌肥大的交叉传递效应中起重要作用。

项目成果

Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens

蛋白质代谢和肌源性祖细胞在运动引起的肌肉肥大中发挥的作用及其与阻力训练方案的关系

• 发表时间: 2012
• 期刊: J. Phys. Fitness Sports Med.
• 作者: Ishii;N.;Ogasawara;R.;Kobayashi;K. and Nakazato;K
• 通讯作者: K

Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone alpha B-crystallin in rat muscles

从大鼠肌肉中微管蛋白与其分子伴侣αB-晶状体蛋白之间的相关性推论微管在成熟横纹肌中的重要作用

• 发表时间: 2009
• 期刊: J. Physiol. Sci.
• 作者: Jee;H.;Sakurai;T.;Kawada;S.;Ishii;N. and Atomi;Y
• 通讯作者: Y

Time Course Change of IGF1/Akt/mTOR/p70s6k Pathway Activation in Rat Gastrocnemius Muscle During Repeated Bouts of Eccentric Exercise.

• 发表时间: 2010-06
• 期刊: Journal of sports science & medicine
• 影响因子: 3.2
• 作者: E. Ochi;N. Ishii;K. Nakazato

筋力増強の・カニズムとその応用

增肌机制及其应用

• 发表时间: 2010
• 作者: 三好美浩;吉本佐雅子;勝野眞吾;内田若希・永尾雄一;石井直方
• 通讯作者: 石井直方

ボディメンテナンスメソッド

身体保养方法

• 发表时间: 2010
• 作者: 笹尾真美;野口いづみ;新美敬太;曽我部健;井出正道;高野宏二;杉山康司;長澤純一;大野秀樹;石井直方
• 通讯作者: 石井直方