Local muscular steroidogenesis and exercise for anti-aging

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Sex steroid hormones are mainly produced and secreted by the ovary, testis, and adrenal cortex and affect diverse physiological processes of target organs or tissues, such as reproductive organs, bones, liver, heart, vasculature, brain, and skeletal muscles. Previously, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. This study examined association of life-style related diseases and sarcopenia in local skeletal and cardiac muscles and intended to apply it to exercise therapy for anti-aging. Our data demonstrated that local steroidogenesis is involved in age-related life-style related diseases and sarcopenia, suggesting that this mechanism provides beneficial information as a basic finding of the exercise therapy for anti-aging prevention.