Creation and Structure-Function Control of Photo-Reactive Proteins and Peptides

以高空间和时间分辨率控制蛋白质和多肽的结构和功能将开创包括活体测量和医疗在内的新技术。本研究构建了光反应蛋白和肽，并对这些生物相关分子的结构和功能进行了光调控。利用该蛋白的光活性、光活性配体在金表面的固定和对其金属离子结合的调节，以及光活性配体对DNA切割的控制，对其进行了结构功能分析。

Control of the structure and function of proteins and peptides with high space and time resolution will initiate new technologies, which include living body measurements and medical treatment. In this research, photo-reactive proteins and peptides were constructed, and photo-control of the structure and function of these biologically -related molecules was performed. The structure-function analysis of the protein with the use of its photoactivity , fixation of a photoactive ligand on a gold surface and regulation of its metal ion binding, and control of DNA cleavage with a photoactive ligand were performed.