Single Cell Deformability Measurement Based on the Combined Technology of Cell Flow Control and its Electric Detection

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An innovative method to effectively detect a characteristic difference in the deformability of red blood cell(RBC) as a typical example of single cells has been proposed in this study and applied to micro-fluidic experiments using a pair of counter-type membrane electrodes carefully designed and mounted on the surface of a microchannel. The flows of high shear rate with which an RBC changes its shape depending on its health condition were introduced in the microchannel. The electrodes monitored the signal patterns of electric resistanceΔR which corresponds to the deformability index of RBC, DI. It was found that DI was closely correlated with the full width of half maximumδofΔR peak, rather than the peak value itself.