Seamless Single Cell Sorting Method Appropriately Appling Shear Flows and Distorted Electric Fields

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Numerical simulation and flow visualization on the motions of a fine spherical polystyrene particle in a microchannel installing thin membrane-type electrodes were made in order to develop an innovative method for fast and seamless sorting of single cell, in particular, red blood cell (RBC). Distorted electric fields around straight- or semi-circle- type electrodes that dielectrophoretic (DEP) forces suitably act on the particle flowing in the channel were numerically predicted. The numerically obtained trajectories of the particles show the good agreement with the visualization results, which can be expected to advance an effective manipulation and sorting of RBCs using DEP.