Evaluation of nanoparticles exposure from surrounding environment and study on their disposition

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The biosafety of nano particles becomes a growing concern. Many experimental studies have shown that nano particles are able to penetrate deeply into the respiratory tract and translocate from the lungs into the systemic circulation. This study investigated the nano particles exposure from surrounding environment. Silica nano particles were selected as the target research particle. The disposition rate of silica nano particle in the air was determined using Low Pressure Impactor and ICP-AES. The results indicated that the silica nano particles concentration in the surrounding air was about 12. 7 ng/m3. The data was used in the disposition model to calculate the amount of silica nano particles in mice organs. The results of disposition model of mice showed that 0. 3 pg of silica nano particles was accumulated in liver. The results of disposition model of human showed that 1200 pg of silica nano particles was accumulated in lung.