Whole-body distribution of 14C-labeled silica nanoparticles and submicron particles after intravenous injection into Mice
Whole-body distribution of 14C-labeled silica nanoparticles and submicron particles after intravenous injection into Mice
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静脉注射小鼠体内 14C 标记二氧化硅纳米颗粒和亚微米颗粒的全身分布
DOI：
10.1007/s11051-012-0849-x
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发表时间：
2012
期刊：
影响因子：
2.5
通讯作者：
Minoru Yoneda
中科院分区：
文献类型：
--
作者：
Nobumitsu Sakai;Masato Takakura;Harutoshi Imamura;Miki Sugimoto;Yasuto Matsui;Hirokazu Miyoshi;Aki Nakayama;Minoru Yoneda
我们分析了14 C-ADP-SiO2纳米颗粒（14 C-ADP-SiO2 nanoparticles）和14 C-ADP-SiO2亚微米颗粒（14 C-ADP-SiO2 submicron particles）静脉注射给ICR小鼠后的全身分布。在注射前合成了14 C-ADP-SiO2纳米粒子和亚微米粒子，粒径分别为19.6和130 nm。类似地，形状是球形的，并且结晶度是无定形的。合成完成后，将14 C-ADP-SiO2纳米颗粒或14 C-ADP-SiO2亚微米颗粒注射小鼠，并在1、2、4、8和24 h后解剖组织。用液体闪烁计数器测量组织中的放射性。结果显示，暴露于14 C-ADP-SiO2纳米颗粒的小鼠在骨骼、皮肤、淋巴结和消化混合物中的滞留百分比至少高出两倍，而暴露于14 C-ADP-SiO2亚微米颗粒的小鼠在肾脏中的滞留百分比在统计学上更高。这两种14 C-ADP-SiO2颗粒主要分布在肌肉、骨骼、皮肤和肝脏中，而几乎不分布在大脑和嗅球中。此外，注射后24小时，14 C-ADP-SiO2纳米颗粒在全身的滞留百分比（62.4%）高于14 C-ADP-SiO2亚微米颗粒（50.7%）。因此，我们认为，14 C-ADP-SiO2纳米颗粒可能比14 C-ADP-SiO2亚微米颗粒更容易滞留在体内，因此，它们可能通过慢性暴露而逐渐积累。
We analyzed the whole-body distribution of14C–ADP-labeled silica nanoparticles (14C–ADP–SiO2nanoparticles) and submicron particles (14C–ADP–SiO2submicron particles) after intravenous injection into ICR mice. The14C–ADP–SiO2nanoparticles and submicron particles were synthesized before the injection and the particle size was 19.6 and 130 nm, respectively. Similarly, the shape was spherical and the crystallinity was amorphous. After the synthesis, we injected mice with the14C–ADP–SiO2nanoparticles or the14C–ADP–SiO2submicron particles and dissected tissues after 1, 2, 4, 8 and 24 h. The radioactivity in the tissues was measured with a liquid scintillation counter. As a result, the retention percentage in bone, skin, lymph nodes, and the digestive mixture was at least twofold higher in the14C–ADP–SiO2nanoparticles-exposed mice, whereas the retention percentage in the kidney was statistically higher in the14C–ADP–SiO2submicron particles-exposed mice. Both types of14C–ADP–SiO2particles mainly translocated to the muscle, bone, skin, and liver, but hardly translocated to the brain and olfactory bulb. Furthermore, the14C–ADP–SiO2nanoparticles had a higher retention percentage (62.4 %) in the entire body at 24-h post-injection than did the14C–ADP–SiO2submicron particles (50.7 %). Therefore, we suggested that the14C–ADP–SiO2nanoparticles might be more likely than the14C–ADP–SiO2submicron particles to be retained in the body, and consequently they might be gradually accumulated by chronic exposure.
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影响因子：
10.8
作者：
Nan, Anjan;Bai, Xia;Ghandehari, Hamidreza
通讯作者：
Ghandehari, Hamidreza
3H-ATP掺入二氧化硅纳米粒子的制备及其扩散释放
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
H. Miyoshi;Yuko Kazumori;Shintaro Nakayama
通讯作者：
Shintaro Nakayama
影响因子：
0.3
作者：
J. Atherton
通讯作者：
J. Atherton
DOI：
10.1080/10934520802171675
发表时间：
2008-01-01
影响因子：
2.1
作者：
Fujiwara, Kitao;Suematsu, Hitoshi;Moritoki, Nobuko
通讯作者：
Moritoki, Nobuko