Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21

癌症相关粘蛋白表聚糖蛋白/Muc21的免疫抑制功能

• 批准号: 21390018
• 负责人: IRIMURA Tatsuro
• 金额: $ 11.65万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390018/
• 关键词: ムチン; 免疫抑制; がん; エピグリカニン; アポトーシス; 細胞接着; レクチン; グリコフォーム; モノクローナル抗体; 胸腺上皮; 樹状細胞

Biological and immunological behaviors of transfectants with mouse or human epiglycanin/MUC21 were investigated and the contribution of glycoforms was assessed. Tansfectants of mouse Muc21 were shown to be less adherent than mock transfectants to culture substrates and extracellular matrix components. These properties were due to interference of integrin functions. The transfectants were less sensitive to treatment with cytotoxic effects. These properties may explain the reason why cells with high Muc21 expression were resistant to immunological cancer surveillance. Similar properties such as resistance to apoptosis were observed with cells transfected with human MUC21.

研究了小鼠或人表聚糖蛋白/MUC21 转染子的生物学和免疫学行为，并评估了糖型的贡献。 小鼠 Muc21 转染子与模拟转染子相比，对培养基质和细胞外基质成分的粘附性较差。 这些特性是由于整合素功能的干扰造成的。 转染子对细胞毒性作用的处理不太敏感。 这些特性可以解释 Muc21 高表达的细胞对免疫癌症监测具有抵抗力的原因。 在用人MUC21转染的细胞中观察到类似的特性，例如抗凋亡。

项目成果

Wisteria floribunda Agglutinin-Positive Mucin 1 Is a Sensitive Biliary Marker for Human Cholangiocarcinoma

• DOI: 10.1002/hep.23654
• 发表时间: 2010-07-01
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Matsuda, Atsushi;Kuno, Atsushi;Narimatsu, Hisashi
• 通讯作者: Narimatsu, Hisashi

IL-17-producing NK1.1– CD27– gdT cells promote tumor malignant progression by inducing inflammatory microenvironment

产生IL-17的NK1.1–CD27–gdT细胞通过诱导炎症微环境促进肿瘤恶性进展

• 发表时间: 2012
• 作者: Hayakawa Y.;Kimura Y.;Tsunekawa N.;Sato-Matsushita M.;Tahara H.;Saiki I.;and Irimura T.
• 通讯作者: and Irimura T.

Effect of MUC1 plasmid DNA and BM-DCs vaccination in an experimental colon carcinogenesis in MUC1 transgenic mice.

MUC1 质粒 DNA 和 BM-DC 疫苗接种对 MUC1 转基因小鼠实验性结肠癌发生的影响。

• 发表时间: 2010
• 作者: Murwanti R;Sugiura D;Denda-Nagai K;Kamata-Sakurai M;Irimura T.
• 通讯作者: Irimura T.

Esophageal squamous carcinoma and normal squamous epithelia express differen tially glycosylated mucin 21.

食管鳞状细胞癌和正常鳞状上皮表达不同的糖基化粘蛋白21。

• 发表时间: 2012
• 作者: Kishimoto K.;et al.;金野真和ら;可野邦行;Tian Yuan
• 通讯作者: Tian Yuan

MUC1 glycoforms have impact on protective immunity against MUC1-expressing tumor cells through the function of antigen presenting cells bearing MGL1/MGL2

MUC1 糖型通过携带 MGL1/MGL2 的抗原呈递细胞的功能，对表达 MUC1 的肿瘤细胞的保护性免疫产生影响

• 发表时间: 2012
• 作者: Kimura A;Denda-Nagai K;Irimura T
• 通讯作者: Irimura T