Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21

研究了小鼠和人表葡聚糖蛋白/MUC21转染体的生物学和免疫学行为，并评价了糖形式的贡献。小鼠Muc21的转染体对培养底物和细胞外基质成分的粘附率低于模拟转染体。这些特性是由于整合素功能的干扰所致。转染者对有细胞毒作用的处理不太敏感。这些特性可能解释了为什么高表达Muc21的细胞对免疫肿瘤监视具有抵抗力。在转染人MUC21的细胞中也观察到了类似的特性，如抗凋亡。

Biological and immunological behaviors of transfectants with mouse or human epiglycanin/MUC21 were investigated and the contribution of glycoforms was assessed. Tansfectants of mouse Muc21 were shown to be less adherent than mock transfectants to culture substrates and extracellular matrix components. These properties were due to interference of integrin functions. The transfectants were less sensitive to treatment with cytotoxic effects. These properties may explain the reason why cells with high Muc21 expression were resistant to immunological cancer surveillance. Similar properties such as resistance to apoptosis were observed with cells transfected with human MUC21.