Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21

研究了转染小鼠或人表胰甘蛋白/MUC21的生物学和免疫学行为，并评估了糖型的贡献。小鼠Muc21的转染物比模拟转染物对培养底物和细胞外基质成分的粘附性更低。这些性质是由于积分素函数的干扰。转染物对细胞毒性作用不太敏感。这些特性可以解释为什么Muc21高表达的细胞对免疫肿瘤监测具有抗性。转染人MUC21的细胞也具有类似的抗凋亡特性。

Biological and immunological behaviors of transfectants with mouse or human epiglycanin/MUC21 were investigated and the contribution of glycoforms was assessed. Tansfectants of mouse Muc21 were shown to be less adherent than mock transfectants to culture substrates and extracellular matrix components. These properties were due to interference of integrin functions. The transfectants were less sensitive to treatment with cytotoxic effects. These properties may explain the reason why cells with high Muc21 expression were resistant to immunological cancer surveillance. Similar properties such as resistance to apoptosis were observed with cells transfected with human MUC21.