A peptide sequence motif which regulates glycoforms

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The Ebola virus envelope glycoprotein(GP) determines the infectivity through their differential degree of interaction with MGL, a C-type lectin, and the interaction depends on the carbohydrate structures. Structural determinations of glycans of Zaire GP, Reston GP, and chimeric GPs clearly demonstrated that 18 amino acid residues in the GPs determines the N-glycan extension, particularly transfer of galactose. A possibility that the sequence determines the retention of the glycoprotein at a specific compartment in Golgi apparatus was also shown. Furthermore, importance of specific residues within the 18 amino acids was established.