Sorting of tyrosine kinases to organelles and signal transduction

酪氨酸激酶参与细胞增殖、分化和细胞运动，其畸变可导致肿瘤转化。在这项研究中，我们发现在Lyn激酶结构域和长链酰基辅酶a合成酶3 （ACSL3）之间发生了激酶活性无关的瞬时蛋白-蛋白相互作用，由此产生的蛋白-蛋白相互作用触发Lyn从高尔基膜出口到细胞表面膜。此外，我们发现Lyn和c-Abl以激酶活性依赖的方式通过染色质结构的变化参与基因表达的调控。

Tyrosine kinases are involved in cell proliferation, differentiation and cell motility, and their aberrations lead to neoplastic transformation. In this study, we showed that a kinase activity-independent and transient protein-protein interaction takes place between the Lyn kinase domain and long-chain acyl-CoA synthetase 3 (ACSL3) and the resulting protein-protein interaction triggers Lyn export from the Golgi membrane to the cell-surface membrane. Furthermore, we found that Lyn and c-Abl are involved in the regulation of gene expression through chromatin structure changes in a kinase activity-dependent manner.