Sorting of tyrosine kinases to organelles and signal transduction

酪氨酸激酶参与细胞增殖、分化和细胞运动，并且它们的畸变导致肿瘤转化。在这项研究中，我们发现，激酶活性独立和短暂的蛋白质-蛋白质相互作用之间发生的林恩激酶结构域和长链酰基辅酶A合成酶3（ACSL 3）和由此产生的蛋白质-蛋白质相互作用触发林恩出口从高尔基体膜细胞表面膜。此外，我们发现，林恩和c-Abl参与调控基因表达，通过染色质结构的变化，激酶活性依赖性的方式。

Tyrosine kinases are involved in cell proliferation, differentiation and cell motility, and their aberrations lead to neoplastic transformation. In this study, we showed that a kinase activity-independent and transient protein-protein interaction takes place between the Lyn kinase domain and long-chain acyl-CoA synthetase 3 (ACSL3) and the resulting protein-protein interaction triggers Lyn export from the Golgi membrane to the cell-surface membrane. Furthermore, we found that Lyn and c-Abl are involved in the regulation of gene expression through chromatin structure changes in a kinase activity-dependent manner.