Development of the next generation of AIDS vaccine candidates based on the immune response of HIV-resistant individuals.

在本研究中，获得了以下结果：1)在阴道和粘膜表面诱导抗病毒ENV或CCR5抗体。2)找到维持ENV或CCR5抗体滴度水平的交叉反应抗原。3)在日本建立非人灵长类动物阴道HIV-1感染模型，由于食蟹猴具有与女性相似的发情周期，因此在非人灵长类动物模型中接种了10000 TCID_<50>/ml的游离SIV（1 ml）、SIV感染细胞和精液的混合物。

In this research, the following results were obtained.1) The antibodies against viral ENV or CCR5 were induced in the vagina and mucosal surface.2) The cross-reacting antigen for maintaining the titer level of antibodies against ENV or CCR5 was found.3) To develop nonhuman primate models for vaginal HIV-1 infection in Japan, it resulted in the conclusion that the nonhuman primate model was inoculated with the mixture of 10000 TCID_<50>/ml of free SIV(1 ml), SIV-infected cells, and semen because cynomolgus monkey shows similar estrous cycle like women.