An interrelation among regulatory mechanisms of cardiac Ca2+channels
An interrelation among regulatory mechanisms of cardiac Ca2+channels
批准号:
21390059
负责人:
KAMEYAMA Masaki
金额:
$5.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We investigated regulation of L-type Ca2+channels by calmodulin(CaM) and phosphorylation. CaM bound to preIQ and IQ regions in the C-terminal of the channel. PKA phosphorylated Ser1574 and Ser1626 as well as Ser1927(guinea-pig). The facilitatory effect of CaM was enhanced by CaMKII-mediated phosphorylation of Thr1603, suggesting a cross-talk between the CaM's effect and channel phosphorylation.
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PKA-mediated phosphorylation modulates the interaction of calmod ulin with cardiac Cav1. 2 channels
PKA 介导的磷酸化调节钙调蛋白与心脏 Cav1 的相互作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Xu J-J, Saud ZA, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao L-Y, Kameyama M.]
通讯作者:
Kameyama M.
モルモット心室筋細胞におけるL型Ca^<2+>チャネルの過酸化水素による活性調節機構
过氧化氢对豚鼠心室肌细胞L型Ca^2+通道活性的调节
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[楊磊, 徐建軍, 蓑部悦子, 封瑞, 亀山亜砂子, 矢沢和人, 亀山正樹]
通讯作者:
亀山正樹
Cav1. 2 Ca^<2+>チャネルC末端部には、複数の機能的Aキナーゼリン酸化部位がある
Cav1.2 Ca^2+通道C末端具有多个功能性A激酶磷酸化位点
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[蓑部悦子, 前田佐知子, 徐建軍, はお麗英, 封瑞, 矢沢和人, 亀山亜砂子, 亀山正樹]
通讯作者:
亀山正樹
Roles of calmodulin and the C-terminal tail ofCav1.2 channel in its activity.
钙调蛋白和Cav1.2通道C末端尾部在其活性中的作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[蓑部悦子, 森誠之, 亀山正樹]
通讯作者:
亀山正樹
Facilitation of L-type Ca2+ channels by hydrogen peroxide in guinea-pig ventricular myocytes.
豚鼠心室肌细胞中过氧化氢对 L 型 Ca2 通道的促进作用。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Lei Yang, Jianjun Xu, Etsuko Minobe, Rei Feng, Asako Kameyama, Kazuto Yazawa, Masaki Kameyama]
通讯作者:
Masaki Kameyama
共 30 条
Study on the regulatory mechanisms of L-type Ca2+ channels
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批准号:15K08181
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
-
财政年份:2015
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负责人:KAMEYAMA Masaki
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依托单位:
Damage Monitoring of Smart Composite Structures using Multi-inputPiezoelectric Fiber Actuators
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批准号:23760094
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:KAMEYAMA Masaki
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依托单位:
Development of Efficient Independent Modal Vibration Measurement/Control Method for Smart Composite Structures and Its Application to Aerospace Structures
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批准号:21760167
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.33万
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财政年份:2009
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负责人:KAMEYAMA Masaki
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依托单位:
Realization of near-infrared spectroscopy (NIRS) as a clinical examination for suicide risk in mood disorders.
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批准号:21591503
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:KAMEYAMA Masaki
-
依托单位:
Molecular mechanisms underlying Ca2^<+>-dependent facilitation and inactivation of L-type Ca^<2+> channels
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批准号:19590210
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:KAMEYAMA Masaki
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依托单位:
Molecular mechanisms of regulation of L-type Ca channels
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批准号:17590189
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:KAMEYAMA Masaki
-
依托单位:
Complexity of the regulation of L-type calcium channels
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批准号:15590188
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2003
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负责人:KAMEYAMA Masaki
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依托单位:
Mechanisms for regulation of L-type Ca channels by intracellular factors
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批准号:13670045
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2001
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负责人:KAMEYAMA Masaki
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依托单位:
Study on the new regulatory mechanisms of L-type calcium channels
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批准号:11670048
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1999
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负责人:KAMEYAMA Masaki
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依托单位:
A new intracellular foctor for regulation of Ca channel.
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批准号:09670051
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:KAMEYAMA Masaki
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依托单位:
Roles of calpastatin and ATP in regulation of the Ca channel
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批准号:06680812
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:KAMEYAMA Masaki
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依托单位:
Mechanisms of Regulation of Calcium Channels
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批准号:02454118
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.69万
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财政年份:1990
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负责人:KAMEYAMA Masaki
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依托单位:
Mechanisms of 'run-down' of calcium channels
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批准号:63570044
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1988
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负责人:KAMEYAMA Masaki
-
依托单位:
海外基金