Analysis of molecular mechanisms that reciprocally regulate growth and differentiation of mature hepatocytes

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Growth and differentiated functions of mature hepatocytes are reciprocally regulated by cell density.(1) We found that a furin-like protease activity is involved in HGF-mediated LAR activation under high-cell density conditions.(2) Using TDO promoter-EGFP transgenic mice, we found that a conserved homologous region exists among the species. Furthermore, C/ EBP-αcan bind its site and activate promoter activity.(3) Proline is an essential amino acid for hepatocyte growth. Proline increased accumulation of cyclin D and E proteins via newly synthesized collagen.