Function and mode of action of Rab family small G proteins in the formation of neuronal network

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Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in the formation of neuronal network. As to Rab3A, we found using the knockout mice that Rabconnectin, the Rab3A-related protein, is involved in neuronal function, probably through formation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in the neuronal network