Function and mode of action of Rab family small G proteins in the formation of neuronal network

RAB家族小G蛋白在囊泡转运过程中起着分子开关的作用。在本研究中，我们重点研究了Rab3A、Rab13及其相关蛋白在神经网络形成中的作用和作用方式。至于Rab3A，我们利用基因敲除的小鼠发现，RabConnectin是Rab3A相关蛋白，可能通过形成突触组织参与神经元功能。我们还发现，Rab13-JRAb系统调控着PC12细胞突起延伸过程中肌动蛋白细胞骨架的重组。我们的结果表明，该系统可能同时协调神经网络中的囊泡运输和肌动蛋白细胞骨架重组。

Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in the formation of neuronal network. As to Rab3A, we found using the knockout mice that Rabconnectin, the Rab3A-related protein, is involved in neuronal function, probably through formation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in the neuronal network