Analysis of lung adenocarcinoma according to molecular biological classification

根据分子生物学分类分析肺腺癌

• 批准号: 21390110
• 负责人: YATABE Yasushi
• 金额: $ 11.56万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390110/
• 关键词: 呼吸器; 縦隔(肺腺癌、分子病理学); 肺癌; 遺伝子変異; 上皮増殖因子受容体; 腺癌; KRAS遺伝子; 生物学的腫瘍分類; 腫瘍内多様性; ALK遺伝子

We carried out this study according to four themes that we initially laid out. For analysis of preinvasive and in-situ lesions, we could establish definition of adenocarcinoma in-situ in the new adenocarcinoma classification as a member of the IASLC pathology panel. We are still analyzing multiple lesions using SNP array that is of our second theme. To the third theme of intra-tumor heterogeneity, we could show that different EGFR mutation status within individual tumors was caused by combination of heterogeneous distribution of gene amplification and mutation allele specific imbalance, and we called the phenomenon"pseudo-heterogeneity". We have also achieved sufficient results for the fourth theme, because we participated in international collaborative studies to establish ALK diagnostic algorithm and established it as a guidance requested from the Japanese Lung Cancer Association.

我们根据最初提出的四个主题开展了这项研究。为了分析浸润前和原位病变，我们可以作为IASLC病理小组成员在新的腺癌分类中建立原位腺癌的定义。我们仍然使用SNP阵列分析多个病变，这是我们的第二个主题。对于肿瘤内异质性的第三个主题，我们可以证明个体肿瘤内不同的EGFR突变状态是由基因扩增的异质分布和突变等位基因特异性失衡共同造成的，我们将这种现象称为“伪异质性”。我们在第四个主题上也取得了足够的成果，因为我们参与了国际合作研究，建立了ALK诊断算法，并根据日本肺癌协会的要求建立了指导。

项目成果

Morphological and Biological Characteristics of Lung Adenocarcinomas Harboring EGFR, KRAS, BRAF, HER2, and EML4-ALK Gene Alterations

携带 EGFR、KRAS、BRAF、HER2 和 EML4-ALK 基因改变的肺腺癌的形态和生物学特征

• 发表时间: 2009
• 作者: 阿南勝宏;大上直秀;坂本直也;仙谷和弘;浦岡直礼;内藤寛;HtooZarniOo;野口剛;安井弥;Yatabe Y
• 通讯作者: Yatabe Y

Is the EGFR Mutation Distributed Heterogeneously within Tumors?

EGFR 突变在肿瘤内分布是否异质？

• 发表时间: 2011
• 作者: 田原康玄;他;Kazue Hashimoto-Torii;澤洋文;Yasushi Yatabe
• 通讯作者: Yasushi Yatabe

EGFR mutations and the terminal respiratory unit

• DOI: 10.1007/s10555-010-9205-8
• 发表时间: 2010-02
• 期刊: Cancer and Metastasis Reviews
• 影响因子: 9.2
• 作者: Y. Yatabe

Role of TTF-1 and EGFR Developmental Pathways In Lung Adenocarcinoma

TTF-1 和 EGFR 发育途径在肺腺癌中的作用

• 发表时间: 2011
• 作者: Shigemoto Fujii;Tomohiro Sawa;Hideshi Ihara;Takaaki Akaike;Oue N;Yasushi YATABE
• 通讯作者: Yasushi YATABE

Pitfalls for EGFR mutation specific antibodies, oral workshop Molecular classification of lung carcinoma(1): Adenocarcinoma, oral workshop Standardization of IHC for ALK

EGFR 突变特异性抗体的陷阱，口腔研讨会 肺癌分子分类(1)：腺癌，口腔研讨会 ALK IHC 标准化

• 发表时间: 2011
• 作者: Endo M;Oda Y;Tamiya S;et al.;Yasushi YATABE
• 通讯作者: Yasushi YATABE