Translational TGF-β Research for Diagnosis, Treatment, and Prevention of Cancer

转化生长因子-β相关分子TMEPAI、TSC 22 D4（THG-1）和MafK被阐明可启动致癌活性并促进恶性进展。对这些癌基因作用机制的研究为肿瘤的防治提供了新的靶分子。本研究建立了TMEPAI、TSC 22 D4、MafK、Gpnmb等的单克隆抗体，为临床病理研究和肿瘤诊断奠定了基础。

Transforming growth factor-β-related molecules TMEPAI, TSC22D4 (THG-1), and MafK were elucidated to initiate carcinogenic activities and promote malignant progression. Study on the molecular mechanisms how these oncogenes functioning provided the novel target molecules for cancer treatment and prevention. We established monoclonal antibodies for TMEPAI, TSC22D4, MafK, Gpnmb and so on. These antibodies will open the application of these works for clinicopathological research and cancer diagnosis.