Elucidation of interaction between malaria parasites and salivary glands using transgenic mosquitoes
Elucidation of interaction between malaria parasites and salivary glands using transgenic mosquitoes
批准号:
21390126
负责人:
YOSHIDA Shigeto
金额:
$10.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
We have successfully expressed vaccine antigens in the salivary glands of anopheline mosquitoes using the salivary gland-specific promoter. We observed that the transgenic mosquitoes released saliva containing the vaccine antigen through their proboscis. We made another transgenic mosquito expressing anti-malaria antibody in the salivary glands. The transgenic mosquito strongly impaired malaria transmission from mosquito to host.
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マラリアワクチン候補タンパクPfCSPを唾液腺に発現する遺伝子操作ハマダラカの作製
创建基因工程按蚊,在唾液腺中表达疟疾疫苗候选蛋白 PfCSP
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[南雲浩志, 山本大介, 吉田栄人]
通讯作者:
吉田栄人
A Model for "Flying Vaccinator" : A transgenic anopheline mosquito delivers the leishmania vaccine antigen SP15 via blood feeding
“飞行疫苗接种者”模型:转基因按蚊通过吸血输送利什曼原虫疫苗抗原 SP15
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[吉田栄人, 山本大介, 南雲浩志]
通讯作者:
南雲浩志
組換え蚊を用いたマラリア対策
使用重组蚊子对抗疟疾
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kamiryo Y., Eta M., Yamada H., Harano M., Yajima T., Harano M., Tatsugami K., Hamaguchi M., Takeuchi A., Naito S., and Yoshikai Y., 吉田栄人]
通讯作者:
吉田栄人
昆虫ウイルスベクターを用いた新規マラリアワクチンの開発
利用昆虫病毒载体开发新型疟疾疫苗
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[當山清吾, 梅村正幸, 芳田裕子, 矢作綾野, 安田直子, 中江進, 岩倉洋一郎, 松崎吾朗, 吉田栄人]
通讯作者:
吉田栄人
ワクチン抗原を唾液成分として発現・分泌するトランスジェニックハマダラカの作製-蛍光タンパクによる唾液の可視化を用いた解析-
创建表达和分泌疫苗抗原作为唾液成分的转基因按蚊 -使用荧光蛋白对唾液进行可视化分析-
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本大介, 南雲浩志, 吉田栄人, 松岡裕之]
通讯作者:
松岡裕之
共 41 条
Development of a new immunostimulatory drug for non-haemolytic alternative to PQ.
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批准号:18K19394
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.08万
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财政年份:2018
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负责人:YOSHIDA Shigeto
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Quantitative analysis and development of a computer-aided system of gastrointestina endoscopic image
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:YOSHIDA Shigeto
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Development of a novel anti-platelet drug targeted for collagen-induced platelet aggregation
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批准号:24659460
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2012
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负责人:YOSHIDA Shigeto
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A practice and application of lingusitc knowledge in the revitalization of the Yucatec Maya
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批准号:23520485
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2011
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负责人:YOSHIDA Shigeto
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依托单位:
A Study on the Re-territorialization of Mayan Discource in Daily Practices
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批准号:19401036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.82万
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财政年份:2007
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负责人:YOSHIDA Shigeto
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依托单位:
Elucidation of parasitic adaptability between malaria parasite-anopheline mosquito using transgenic mosquitoes
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批准号:18390130
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.55万
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财政年份:2006
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负责人:YOSHIDA Shigeto
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依托单位:
Elucidation of mosquito-malaria parasite interaction using genetically engineered mosquitoes
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批准号:16590345
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2004
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负责人:YOSHIDA Shigeto
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依托单位:
An Anthropological and Historical Study on the Production and Consumption of Mayan Images.
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批准号:14401009
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.4万
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财政年份:2002
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负责人:YOSHIDA Shigeto
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依托单位:
Generation of transgenic anopheline mosquitoes refractory to malaria parasite by using gene manipulation
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批准号:13670253
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2001
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负责人:YOSHIDA Shigeto
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依托单位:
A Medico-anthropological Study on Religious Practices of the Yucatec Maya in Mexico.
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批准号:11610315
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1999
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负责人:YOSHIDA Shigeto
-
依托单位:
海外基金