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Intracellularsignals regulating cytokine production in basophils

Intracellularsignals regulating cytokine production in basophils
调节嗜碱性粒细胞细胞因子产生的细胞内信号
批准号:
21390149
负责人:
TAKI Shinsuke
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012

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中文摘要
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英文摘要
Mechanisms regulating interleukin-4 (IL-4) production in murine basophils were studied. Basophils, when resting,produce IL-4 in response to IL-3 but not F_RI crosslinkage, whereas activated basophils produce the cytokine upon FcεRI crosslinkage but not IL-3 stimulation. The transcriptional repressor Bcl-6 and the suppressive cell surface molecule PIR-B were identified to negatively regulate F_RI signals in resting basophils and IL-3 signals in activated basophils, respectively.
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会议论文
好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
嗜碱性粒细胞IL-4产生诱导信号转导机制及Th2分化
DOI: --
发表时间: 2010
期刊: 臨床免疫・アレルギー科
影响因子: --
作者: [小田朗永, 瀧伸介]
通讯作者: 瀧伸介
Th2分化と好塩基球
Th2分化和嗜碱性粒细胞
DOI: --
发表时间: 2010
期刊: 実験医学
影响因子: --
作者: [肥田重明, 瀧伸介]
通讯作者: 瀧伸介
The ITAM-Syk signaling pathway common for divergent IL-4-inducing basophil stimulants
ITAM-Syk 信号通路常见于不同的 IL-4 诱导嗜碱性粒细胞兴奋剂
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Sitbon, M., et al., Koinuma N, 瀧伸介]
通讯作者: 瀧伸介
DOI: 10.1093/cvr/cvq397
发表时间: 2011-05-01
期刊: CARDIOVASCULAR RESEARCH
影响因子: 10.8
作者: [Hata, Takeki, Takahashi, Masafumi, Ikeda, Uichi]
通讯作者: Ikeda, Uichi
18
    Positive and negative regulation of cytokine signals in basophils
    • 批准号:
      24590578
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Mechanism for sensing protease allergens by basophils
    • 批准号:
      22659096
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.0万
    • 财政年份:
      2010
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity
    • 批准号:
      19590494
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Gene Expression in Immunological Tolerance and Immune Dysfunctions Caused by Its Disturbance
    • 批准号:
      15390159
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.98万
    • 财政年份:
      2003
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    海外基金