Intracellularsignals regulating cytokine production in basophils
Intracellularsignals regulating cytokine production in basophils
批准号:
21390149
负责人:
TAKI Shinsuke
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
Mechanisms regulating interleukin-4 (IL-4) production in murine basophils were studied. Basophils, when resting,produce IL-4 in response to IL-3 but not F_RI crosslinkage, whereas activated basophils produce the cytokine upon FcεRI crosslinkage but not IL-3 stimulation. The transcriptional repressor Bcl-6 and the suppressive cell surface molecule PIR-B were identified to negatively regulate F_RI signals in resting basophils and IL-3 signals in activated basophils, respectively.
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好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
嗜碱性粒细胞IL-4产生诱导信号转导机制及Th2分化
DOI:
--
发表时间:
2010
期刊:
臨床免疫・アレルギー科
影响因子:
--
作者:
[小田朗永, 瀧伸介]
通讯作者:
瀧伸介
Th2分化と好塩基球
Th2分化和嗜碱性粒细胞
DOI:
--
发表时间:
2010
期刊:
実験医学
影响因子:
--
作者:
[肥田重明, 瀧伸介]
通讯作者:
瀧伸介
The ITAM-Syk signaling pathway common for divergent IL-4-inducing basophil stimulants
ITAM-Syk 信号通路常见于不同的 IL-4 诱导嗜碱性粒细胞兴奋剂
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sitbon, M., et al., Koinuma N, 瀧伸介]
通讯作者:
瀧伸介
DOI:
10.1093/cvr/cvq397
发表时间:
2011-05-01
期刊:
CARDIOVASCULAR RESEARCH
影响因子:
10.8
作者:
[Hata, Takeki, Takahashi, Masafumi, Ikeda, Uichi]
通讯作者:
Ikeda, Uichi
マウス好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
小鼠嗜碱性粒细胞中 IL-4 产生诱导的信号转导机制和 Th2 分化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Toyabe, S, 瀧伸介]
通讯作者:
瀧伸介
共 18 条
Positive and negative regulation of cytokine signals in basophils
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批准号:24590578
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
-
财政年份:2012
-
负责人:TAKI Shinsuke
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依托单位:
Mechanism for sensing protease allergens by basophils
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批准号:22659096
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.0万
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财政年份:2010
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负责人:TAKI Shinsuke
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依托单位:
Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity
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批准号:19590494
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:TAKI Shinsuke
-
依托单位:
Gene Expression in Immunological Tolerance and Immune Dysfunctions Caused by Its Disturbance
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批准号:15390159
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.98万
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财政年份:2003
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负责人:TAKI Shinsuke
-
依托单位:
Studies on the regulatory mechanisms of type I interferons for T cell functions.
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批准号:13670313
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2001
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负责人:TAKI Shinsuke
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依托单位:
Elucidation of mechanism of NK cell activation
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批准号:11670312
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:TAKI Shinsuke
-
依托单位:
Studies on the regulatory mechanisms of V (D) J rearrangement using gene-inserted mice.
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批准号:08839005
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.54万
-
财政年份:1996
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负责人:TAKI Shinsuke
-
依托单位:
海外基金