Mechanism for sensing protease allergens by basophils
Mechanism for sensing protease allergens by basophils
批准号:
22659096
负责人:
TAKI Shinsuke
金额:
$2.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.
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好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
嗜碱性粒细胞IL-4产生诱导信号转导机制及Th2分化
DOI:
--
发表时间:
2010
期刊:
臨床免疫・アレルギー科
影响因子:
--
作者:
[小田朗永, 瀧伸介]
通讯作者:
瀧伸介
Th2分化と好塩基球
Th2分化和嗜碱性粒细胞
DOI:
--
发表时间:
2010
期刊:
実験医学
影响因子:
--
作者:
[肥田重明, 瀧伸介]
通讯作者:
瀧伸介
Regulation of B cell function and development through IRF-2 in type I interferon receptor-dependent and-independent mechanisms
IRF-2 在 I 型干扰素受体依赖性和非依赖性机制中调节 B 细胞功能和发育
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Mi-ichi F., Abu Y.M., Nakada-Tsukui K., Kawai S., Nozaki T., Wakayama Y, Kento Minamino]
通讯作者:
Kento Minamino
IL-15-independent generation of memory-like' innate' CD8+ T cells in IRF-2-deficient mice
IRF-2缺陷小鼠中不依赖IL-15产生记忆样“先天”CD8 T细胞
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[T. Notake, A. Oda, H. Sanjo, S. Hida, S. Taki]
通讯作者:
S. Taki
Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses
嗜碱性粒细胞利用其 FcRγ 相关细胞表面分子感知各种外部信号,产生 IL-4 来引发 Th2 反应
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[S. Hida, A. Oda, I. Koshi, S. Taki]
通讯作者:
S. Taki
共 17 条
Positive and negative regulation of cytokine signals in basophils
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批准号:24590578
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
-
财政年份:2012
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负责人:TAKI Shinsuke
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依托单位:
Intracellularsignals regulating cytokine production in basophils
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批准号:21390149
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2009
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负责人:TAKI Shinsuke
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依托单位:
Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity
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批准号:19590494
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
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负责人:TAKI Shinsuke
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依托单位:
Gene Expression in Immunological Tolerance and Immune Dysfunctions Caused by Its Disturbance
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批准号:15390159
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.98万
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财政年份:2003
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负责人:TAKI Shinsuke
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依托单位:
Studies on the regulatory mechanisms of type I interferons for T cell functions.
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批准号:13670313
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2001
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负责人:TAKI Shinsuke
-
依托单位:
Elucidation of mechanism of NK cell activation
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批准号:11670312
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:TAKI Shinsuke
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依托单位:
Studies on the regulatory mechanisms of V (D) J rearrangement using gene-inserted mice.
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批准号:08839005
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.54万
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财政年份:1996
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负责人:TAKI Shinsuke
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依托单位:
海外基金