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Mechanism for sensing protease allergens by basophils

Mechanism for sensing protease allergens by basophils
嗜碱性粒细胞感知蛋白酶过敏原的机制
批准号:
22659096
负责人:
TAKI Shinsuke
金额:
$2.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.
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会议论文
好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
嗜碱性粒细胞IL-4产生诱导信号转导机制及Th2分化
DOI: --
发表时间: 2010
期刊: 臨床免疫・アレルギー科
影响因子: --
作者: [小田朗永, 瀧伸介]
通讯作者: 瀧伸介
Th2分化と好塩基球
Th2分化和嗜碱性粒细胞
DOI: --
发表时间: 2010
期刊: 実験医学
影响因子: --
作者: [肥田重明, 瀧伸介]
通讯作者: 瀧伸介
Regulation of B cell function and development through IRF-2 in type I interferon receptor-dependent and-independent mechanisms
IRF-2 在 I 型干扰素受体依赖性和非依赖性机制中调节 B 细胞功能和发育
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Mi-ichi F., Abu Y.M., Nakada-Tsukui K., Kawai S., Nozaki T., Wakayama Y, Kento Minamino]
通讯作者: Kento Minamino
IL-15-independent generation of memory-like' innate' CD8+ T cells in IRF-2-deficient mice
IRF-2缺陷小鼠中不依赖IL-15产生记忆样“先天”CD8 T细胞
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [T. Notake, A. Oda, H. Sanjo, S. Hida, S. Taki]
通讯作者: S. Taki
17
    Positive and negative regulation of cytokine signals in basophils
    • 批准号:
      24590578
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Intracellularsignals regulating cytokine production in basophils
    • 批准号:
      21390149
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2009
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity
    • 批准号:
      19590494
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    Gene Expression in Immunological Tolerance and Immune Dysfunctions Caused by Its Disturbance
    • 批准号:
      15390159
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.98万
    • 财政年份:
      2003
    • 负责人:
      TAKI Shinsuke
    • 依托单位:
    海外基金