Molecular mechanism of T cell development in Notch signal mediated nitch

Notch信号介导的缺口中T细胞发育的分子机制

• 批准号: 21390154
• 负责人: HABU Sonoko
• 金额: $ 11.81万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390154/
• 关键词: 免疫学; 胸腺ノッチ; T細胞分化; ノッチシグナル

In this study, we showed that in theT cell developing pathway, GATA3 and Runx1, T cell specific transcription factors, are induced to express correlatively to Notch receptor on immature T cell in the thymus. Notch ligand required for T cells development is also characterized. The over-expression of these transcription factors impaired the early stage developing pathway. Collectively, developing stage specific Notch signaling is suggested regulate the expression of both transcription factors. We also established human Notch L transgenic mice.

在本研究中，我们发现在Thet细胞发育过程中，T细胞特异性转录因子GATA3和RUNX1被诱导在胸腺未成熟T细胞上表达与Notch受体相关的表达。对T细胞发育所需的缺口配体也进行了表征。这些转录因子的过度表达损害了早期发育途径。总的来说，发育阶段特异的Notch信号被认为调节这两种转录因子的表达。我们还建立了人Notch L转基因小鼠。

项目成果

Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human IL1RL1/ST2 Promoter

• DOI: 10.2332/allergolint.12-oa-0424
• 发表时间: 2012-09-01
• 期刊: ALLERGOLOGY INTERNATIONAL
• 影响因子: 6.8
• 作者: Baba, Yosuke;Maeda, Keiko;Nishiyama, Chiharu
• 通讯作者: Nishiyama, Chiharu

Evidence for the coupling of DNA replication control and lineage choice into CD4/8 thymocytes(CD4/8胸腺細胞分化とDNA複製制御は共役する)

DNA复制控制和谱系选择耦合到CD4/8胸腺细胞的证据（CD4/8胸腺细胞分化和DNA复制控制是耦合的）

• 发表时间: 2009
• 作者: Sato T;Chiba T;Sugou T;Satake M;Habu S
• 通讯作者: Habu S

GATA-3 regulates contact hyperresponsiveness in a murine model of allergic dermatitis.

• DOI: 10.1016/j.imbio.2011.10.009
• 发表时间: 2012-04
• 期刊: Immunobiology
• 影响因子: 2.8
• 作者: H. Tamauchi;Y. Amoh;M. Itoh;M. Terashima;M. Masuzawa;S. Habu;K. Katsuoka;K. Iwabuchi

Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double negative to double positive stages.

Runx1转录因子的过度表达会损害胸腺细胞从双阴性到双阳性阶段的发育。

• 发表时间: 2010
• 期刊: Immunology (印刷中)
• 作者: Won Fen Wong;他
• 通讯作者: 他

GATA2 and Sp1 Positively Regulate the c-kit Promoter in Mast Cells

• DOI: 10.4049/jimmunol.1001228
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Maeda, Keiko;Nishiyama, Chiharu;Okumura, Ko
• 通讯作者: Okumura, Ko