Models for studying mechanism of autoimmune disease
研究自身免疫性疾病机制的模型
基本信息
- 批准号:07044295
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for international Scientific Research
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project, we aimed to obtain the animal model with antigen specific tolerance and its break using T cell reseptor trangenic mice (TCR-Tg). This year, we have mainly tried to make the tolerance-induction system and resulted in the followings. (1) In OVA feeded OVA-specific TCR-Tg, suppressive production of Th1-type cytokines was detectable in spleen cells without priming of OVA injection. This suppresive effect was recovered by adding IL-2. The serum level of IgE level was also reduced in the mice. In previous system using non-TCR-Tg, antigen priming is required for inducing tolerance, and consequently, it has been unclear when and where tolerance is acqired. This issue was clarified in the present system. (2) Another tolerance system was succeeded by transplantation of OVA transfectants in the TCR-Tg. Furthermore, OVA tg mice were produced and its expression is under examination. These mice are more appropriate model for investigating tolerance and its breaking-mechanism of auto-reactive T cells.
本课题旨在利用T细胞受体转基因小鼠(TCR-Tg)建立抗原特异性免疫耐受及其破坏的动物模型。今年,我们主要尝试了容忍诱导系统,并取得了以下成果。(1)在OVA饲养的OVA特异性TCR-Tg,抑制生产的Th 1型细胞因子在脾细胞中检测到没有引发的OVA注射。这种抑制作用通过加入IL-2而恢复。小鼠血清IgE水平也降低。在以前使用非TCR-Tg的系统中,需要抗原引发以诱导耐受,因此,不清楚何时以及在何处获得耐受。这个问题在现行制度中得到澄清。(2)另一种耐受系统通过将OVA转染子移植到TCR-Tg中而成功。此外,还制备了OVA tg小鼠,并对其表达进行了检测。这些小鼠是研究自身反应性T细胞耐受及其破坏机制的理想模型。
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hideki, Nozaki: "Regulation of NK activity by the adiministration of bromocriptine in haloperidol treated mice." Brain, Behavior, and Immunity in press. (in press). (1996)
Hideki, Nozaki:“通过在氟哌啶醇治疗的小鼠中施用溴隐亭来调节 NK 活性。”
- DOI:
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- 影响因子:0
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Kazushi,Urano: "PUVA suppresses the expression of cell adhesion molecules of lymphocytes." Exp.Dermatol.4. 36-41 (1995)
Kazushi,Urano:“PUVA 抑制淋巴细胞的细胞粘附分子的表达。”
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- 影响因子:0
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- 通讯作者:
Yoshitake, Tanaka: "Prolonged inhibition of an antigen-specific IgE response in vivo by monoclonal antibody against lymphocyte function-associated antigen-1" Eur.J.Immunol.25. 1555-1558 (1995)
Yoshitake,Tanaka:“针对淋巴细胞功能相关抗原 1 的单克隆抗体对体内抗原特异性 IgE 反应的长期抑制”Eur.J.Immunol.25。
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- 影响因子:0
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Soichi,Kuge: "Interleukin-12 augments the generation of autologous tumor-reactive CD8^+ cytotoxic T lymphocytes from tumor-infiltrating lymphocytes." Jpn.J.Cancer Res.86. 135-139 (1995)
Soichi, Kuge:“Interleukin-12 增强了肿瘤浸润淋巴细胞中自体肿瘤反应性 CD8+ 细胞毒性 T 淋巴细胞的生成。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Yoshitaka,Tanaka: "Prolonged inhibition of an antigen-specific IgE response in vivo by monoclonal antibody against lymphocyte function-associated antigen-1" Eur.J.Immunol.25. 1555-1558 (1995)
Yoshitaka,Tanaka:“针对淋巴细胞功能相关抗原 1 的单克隆抗体对体内抗原特异性 IgE 反应的长期抑制”Eur.J.Immunol.25。
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- 影响因子:0
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HABU Sonoko其他文献
Involvement of commensal bacteria in thymic Aire expression.
共生细菌参与胸腺 Aire 表达。
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
NAKAJIMA Akihito;NEGISHI Naoko;TSURUI Hiromichi;NANNO Masanobu;YAGITA Hideo;OKUMURA Ko;HABU Sonoko - 通讯作者:
HABU Sonoko
HABU Sonoko的其他文献
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{{ truncateString('HABU Sonoko', 18)}}的其他基金
Molecular mechanism of T cell development in Notch signal mediated nitch
Notch信号介导的缺口中T细胞发育的分子机制
- 批准号:
21390154 - 财政年份:2009
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Differentiation-induction of antibody producing human B cells from cord blood CD34+ cells in mice for generating monoclonal antibody used in clinical therapy
从小鼠脐带血 CD34 细胞中分化诱导产生抗体的人 B 细胞,以产生用于临床治疗的单克隆抗体
- 批准号:
12557032 - 财政年份:2000
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Regulatory mechanism of T cell activation in NOD mice
NOD小鼠T细胞活化的调控机制
- 批准号:
09044336 - 财政年份:1997
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for international Scientific Research
Molecular mechanism of selective development in thymocytes analysing DP specific molcules
胸腺细胞选择性发育的分子机制分析DP特异性分子
- 批准号:
09470098 - 财政年份:1997
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Joint study of antigen presenting activity in NOD mice
NOD小鼠抗原呈递活性的联合研究
- 批准号:
08044322 - 财政年份:1996
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for international Scientific Research
The molecular mechanism of TCR repertoire generation and coreceptor expression
TCR库生成和辅助受体表达的分子机制
- 批准号:
07457591 - 财政年份:1995
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Establishment of in vitro experimental model for studying molecular mechanism of self-reactive T cell clone
研究自身反应性T细胞克隆分子机制的体外实验模型的建立
- 批准号:
04454213 - 财政年份:1992
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Studies of selection mechanism against self reactive T cell clones during intrathymic development
胸腺内发育过程中针对自身反应性T细胞克隆的选择机制研究
- 批准号:
03044130 - 财政年份:1991
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for international Scientific Research
Study of T lymphocytes which develop in the extrathymic tissues.
研究胸腺外组织中发育的 T 淋巴细胞。
- 批准号:
61480139 - 财政年份:1986
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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