Memory Th1/Th2 cell differentiation and its epigenetic regulation

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Immunological Memory is a central theme in acquired immunity. The findings from the research on Immunological Memory will contribute to the development of more effective and safer vaccines against infectious diseases, as well as can be beneficial to the development of therapeutic vaccines for controlling so called pathogenic immune memory cells that trigger allergy or autoimmune diseases, and furthermore, to the development of vaccines for cancer. In this study, we found that Polycomb group molecule EZH2 and Trithorax group molecules Men-1 control the generation and functional maintenance of Th2 memory cells.