NKT cell-based immunotherapy for cancer

基于 NKT 细胞的癌症免疫疗法

• 批准号: 17016010
• 负责人: NAKAYAMA Toshinori
• 金额: $ 29.57万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016010/
• 关键词: 免疫学; 発生・分化; 癌; トランスレーショナルリサーチ; 糖鎖; 免疫; 糖類

To evaluate the safety, immune responses and antitumor responses after the administration of α-Galactosylceramide (αGalCer; KRN7000)-pulsed APCs, a phase I-II study in patients with non-small cell lung cancer (NSCLC) was carried out. αGalCer-pulsed APCs (1x10 9/m2) were intravenously administered four times to 17 cases. The estimated median survival time (MST) of the 17 cases was 18.6 months. Ten patients who displayed increased IFN-g producing cells (≥2 fold) showed prolonged MST (31.9 months) as compared to poor-responder patients (n=7, 9.7 months). The administration of αGalCer-pulsed APCs was well tolerated and was accompanied by the successful induction of NKT cell-dependent immune responses. These results are encouraging and warrant further evaluation for survival benefit of this immunotherapy.

为了评价α-半乳糖神经酰胺（αGalCer; KRN 7000）脉冲的APC给药后的安全性、免疫应答和抗肿瘤应答，在非小细胞肺癌（NSCLC）患者中进行了I-II期研究。17例患者静脉注射α GalCe脉冲的APCs（1 × 10 9/m2）4次。中位生存期（MST）为18.6个月。10例IFN-g产生细胞增加（≥2倍）的患者与低应答患者（n=7，9.7个月）相比，MST延长（31.9个月）。α GalCer脉冲APC的给药耐受性良好，并伴随着NKT细胞依赖性免疫应答的成功诱导。这些结果是令人鼓舞的，值得进一步评估这种免疫疗法的生存益处。

项目成果

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.

• DOI: 10.1084/jem.20080698
• 发表时间: 2008-11-24
• 期刊: The Journal of experimental medicine
• 作者: Terashima A;Watarai H;Inoue S;Sekine E;Nakagawa R;Hase K;Iwamura C;Nakajima H;Nakayama T;Taniguchi M
• 通讯作者: Taniguchi M

Dendritic cell maturation by CD11c- T cells and Vα24+ natural killer T-cell activation by α-galactosylceramide

• DOI: 10.1002/ijc.21197
• 发表时间: 2005-11-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Ishikawa, E;Motohashi, S;Nakayama, T
• 通讯作者: Nakayama, T

Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model.

小鼠哮喘模型中 T 淋巴细胞积累和病灶形成的颜色编码实时细胞成像。

• 发表时间: 2010
• 期刊: J Allergy Clin. I m m u n o l. 125
• 作者: Hasegawa;A.;Hayashi;K.;Kishimoto;H.;Yang;M.;Tofukuji;S.;Suzuki;K.;Nakajima;H.;Hoffman;R.M.;Shirai;M.;Nakayama;T.
• 通讯作者: T.

Bmi1 regulates memory Th cell survival via repression of the Noxa gene

Bmi1 通过抑制 Noxa 基因调节记忆 Th 细胞的存活

• 发表时间: 2009
• 期刊: Proceedings of the 2^<nd> European Congress of Immunology
• 作者: Yamashita;M.
• 通讯作者: M.

Initiation and maintenance of Th2 cell identity. Truncated title : Regulation of Th2 responses

Th2 细胞身份的启动和维持。

• 发表时间: 2008
• 期刊: Curr. Opin. Immunol. 20 : 20
• 作者: Nakayama;T
• 通讯作者: T