The effects of"Preemptive Infection Control" in critical care center

在重症监护中心引入插管患者预防性接触预防措施后，不仅插管患者，而且所有患者的医疗相关MRSA感染（HA-MRSA感染）发生率均显著降低。重症监护中心HA-MRSA感染的危险因素为入院24小时内插管、开放性伤口、抗生素治疗和类固醇使用。中性粒细胞胞外陷阱（NETs）在呼吸道感染后迅速在痰液中表达，随着感染的消退而减少。net在血液中不仅对感染有反应，而且对非感染性严重损伤也有反应。有必要明确NETs的临床意义。

After introduction of preemptive contact precautions for intubated patients in critical care center, incidence of healthcare-associated MRSA infection (HA-MRSA infection) significantly decreased in not only intubated patients, but also all the patients. Risk factors for HA-MRSA infection in critical care center were intubation, open wound, antibiotic treatments, and use of steroids, all within 24hrs of admission. Neutrophil extracellular traps(NETs) were promptly expressed in sputum after respiratory infection, and decreased as infection subsided. NETs were expressed in blood in response to not only infection but also noninfectious severe insults. It is necessary to clarify clinical significance of NETs.