MicroRNAs as biomarkers for drug-induced liver injury

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Because of the significant adverse drug reactions associated with hepatotoxicity, several drugs have been removed from the pharmaceutical market. In most cases, the mechanisms of the hepatotoxicity are unknown and predictive experimental animal models are lacking. Thus, experimental animal models of drug-induced liver injury will enable to perform comprehensive analyses for predictive toxicity studies. The miRNA research in the metabolism of xenobiotics and endobiotics and in toxicology has only recently been established. We performed studies with the following titles,(1) Establishment of halothane-induced liver injury in mice and involvement of miRNA on early onset of liver injury.(2) Involvement of immune-related factors and miRNA in the mouse model of diclofenac-induced liver injury.(3) Establishment of the mouse model of flucloxacillin-induced liver injury.(4) Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.(5) Peroxisome proliferator-activator receptor. is regulated by miR-21 and miR-27b in human liver