Molecular epidemiology study on immunogenetic and environmental factors involved in risks of inflammation-associated diseases

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(1) The human epidermal growth factor receptor genotype plays a crucial role in assessing individual susceptibility to lung cancer associated with radiation exposure.(2) The genotype NKG2D, related to NK activity, affects hepatitis C virus(HCV) clearance following HCV infection and determination of treatment course if HCV infection persists, with radiation exposure and this genotype involved in development of hepatocellular carcinoma.(3) The genotypes of DNA repair-related gene polymorphisms may contribute to inter-individual differences in susceptibility to radiation-related cancer development.(4) CD14 and IL18 genotypes might be involved in development of colon cancer among A-bomb survivors, and response to radiation might vary according to these genotypes.