Molecular epidemiology study on immunogenetic and environmental factors involved in risks of inflammation-associated diseases

炎症相关疾病风险中免疫遗传学和环境因素的分子流行病学研究

• 批准号: 21390199
• 负责人: HAYASHI Tomonori
• 金额: $ 11.56万
• 依托单位: 放射線影響研究所 (2011)Radiation Effects Research Foundation (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390199/
• 关键词: ゲノム; 放射線; 炎症; 生活習慣病; 分子疫学; 遺伝子多型; サイトカイン; ケモカイン

(1) The human epidermal growth factor receptor genotype plays a crucial role in assessing individual susceptibility to lung cancer associated with radiation exposure.(2) The genotype NKG2D, related to NK activity, affects hepatitis C virus(HCV) clearance following HCV infection and determination of treatment course if HCV infection persists, with radiation exposure and this genotype involved in development of hepatocellular carcinoma.(3) The genotypes of DNA repair-related gene polymorphisms may contribute to inter-individual differences in susceptibility to radiation-related cancer development.(4) CD14 and IL18 genotypes might be involved in development of colon cancer among A-bomb survivors, and response to radiation might vary according to these genotypes.

(1)人表皮生长因子受体基因型在评估个体对与辐射暴露相关的肺癌的易感性中起着至关重要的作用。(2)基因型NKG2D，与NK活性，影响丙型肝炎病毒（HCV）感染后的清除和治疗过程的确定，如果HCV感染持续存在，与辐射暴露和这种基因型参与肝细胞癌的发展。(3)DNA修复相关基因多态性的基因型可能有助于辐射相关癌症发展的易感性的个体间差异。(4)CD 14和IL 18基因型可能与原子弹幸存者结肠癌的发生有关，并且对辐射的反应可能根据这些基因型而不同。

项目成果

Genetic susceptibility to radiation-associated cancer occurred in atomic-bomb survivors.

原子弹爆炸幸存者对与辐射相关的癌症具有遗传易感性。

• 发表时间: 2011
• 作者: Ma N.;Hayashi T
• 通讯作者: Hayashi T

炎症関連遺伝子多型と原爆放射線被曝の胃および肝がん発症リスクに及ぼす影響

炎症相关基因多态性和原子弹辐射暴露对胃癌和肝癌风险的影响

• 发表时间: 2009
• 作者: Hiraku Y;Kawanishi S;異島優;Hayashi T;Tada-Oikawa S;田口和明;Hayashi T;Ma N.;Hayashi T;小森久和;林奉権;小田切優樹;異島優;林奉権;及川伸二;異島優;森下ゆかり;Mo Yingxi;平田憲史郎;Hayashi T;宮里麻友美;王淑民;林奉権;林奉権;Thanan Raynoo;Masaki Otagiri(Ed);林奉権
• 通讯作者: 林奉権

Associations of Ionizing Radiation and Breast Cancer-Related Serum Hormone and Growth Factor Levels in Cancer-Free Female A-Bomb Survivors

• DOI: 10.1667/rr2631.1
• 发表时间: 2011-11-01
• 期刊: RADIATION RESEARCH
• 影响因子: 3.4
• 作者: Grant, Eric J.;Neriishi, Kazuo;Nakachi, Kei
• 通讯作者: Nakachi, Kei

Effects of NKG2D haplotypes on the cell-surface expression of NKG2D protein on natural killer and CD8 T cells of peripheral blood among atomic-bomb survivors

• DOI: 10.1016/j.humimm.2012.03.003
• 发表时间: 2012-06-01
• 期刊: HUMAN IMMUNOLOGY
• 影响因子: 2.7
• 作者: Imai, Kazue;Hayashi, Tomonori;Nakachi, Kei
• 通讯作者: Nakachi, Kei

Molecular epidemiology of radiation susceptibility to cancer among atomic-bomb survivors

原子弹幸存者癌症辐射易感性的分子流行病学

• 发表时间: 2010
• 作者: Mera K;Watanabe C.;Hayashi T
• 通讯作者: Hayashi T