A cohort study on relationship of tea/coffee drinking, dietary and exercise habits with cardiovascular events and diabetes mellitus, and seroepidemiological analyses on the roles of some biomarkers in predicting the risk of these diseases

茶/咖啡饮用、饮食和运动习惯与心血管事件和糖尿病关系的队列研究，以及一些生物标志物在预测这些疾病风险中的作用的血清流行病学分析

• 批准号: 21390204
• 负责人: TANABE Naohito
• 金额: $ 5.41万
• 依托单位: 新潟県立大学 (2011)Niigata University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390204/
• 关键词: 疫学; コホート研究; 危険因子; 心血管疾患; 虚血性心疾患; 脳卒中; 糖尿病; 罹患; 血清疫学; 死亡; 血清疫学分析; ホモシステイン; ビリルビン

Within 8, 648 participants of our cohort which was built up in 1998, 300 first ever cardiovascular(CVD) events were observed by the end of 2008. Ninety-eight participants were diagnosed to be type 2 diabetes mellitus(T2DM) within the period between the 12th month from baseline and the end of 2008. Habitual consumptions of green tea and milk were associated with decreased risk of total CVD events whereas imbalanced intake of meat and fish, infrequent intake of light-colored vegetables and fruits, and high consumption of rice and grain products were associated with the elevated risk. Low intake of fish and meat was associated with development of T2DM. As for biomarkers measured from stored serum, high-sensitivity CRP was positively associated with the risk of total CVD, ischemic heart disease(IHD) and T2DM ; uric acid was positively associated with the risk of T2DM ; LDL cholesterol was positively associated with and T2DM ; and total bilirubin was negatively associated with the risk of T2DM.

在我们1998年建立的8648名参与者中，到2008年底观察到300例首次心血管（CVD）事件。98名参与者在基线后第12个月至2008年底期间被诊断为2型糖尿病（T2 DM）。习惯性饮用绿色茶和牛奶与心血管疾病总风险降低相关，而肉类和鱼类摄入不平衡，浅色蔬菜和水果摄入不频繁，以及大米和谷物产品的高消费与风险升高相关。鱼类和肉类摄入量低与T2 DM的发生有关。至于从储存的血清中测量的生物标志物，高灵敏度CRP与总CVD、缺血性心脏病（IHD）和T2 DM的风险呈正相关;尿酸与T2 DM的风险呈正相关; LDL胆固醇与T2 DM呈正相关;总胆红素与T2 DM的风险呈负相关。

项目成果

メタボリック症候群診断基準項目と糖尿病発生の関係

代谢综合征诊断标准与糖尿病发生的关系

• 发表时间: 2009
• 期刊: 日本循環器病予防学会誌 44
• 作者: 田邊直仁;他
• 通讯作者: 他

Association of serum hs-CRP levels with the risk of cardiovascular events in a pooled analysis of 2 Japanese cohort studies

两项日本队列研究的汇总分析中血清 hs-CRP 水平与心血管事件风险的关联

• 发表时间: 2012
• 作者: Tanabe N;et al
• 通讯作者: et al