A cohort study on relationship of tea/coffee drinking, dietary and exercise habits with cardiovascular events and diabetes mellitus, and seroepidemiological analyses on the roles of some biomarkers in predicting the risk of these diseases

在我们1998年建立的8648名参与者中，到2008年底观察到300例首次心血管（CVD）事件。98名参与者在基线后第12个月至2008年底期间被诊断为2型糖尿病（T2 DM）。习惯性饮用绿色茶和牛奶与心血管疾病总风险降低相关，而肉类和鱼类摄入不平衡，浅色蔬菜和水果摄入不频繁，以及大米和谷物产品的高消费与风险升高相关。鱼类和肉类摄入量低与T2 DM的发生有关。至于从储存的血清中测量的生物标志物，高灵敏度CRP与总CVD、缺血性心脏病（IHD）和T2 DM的风险呈正相关;尿酸与T2 DM的风险呈正相关; LDL胆固醇与T2 DM呈正相关;总胆红素与T2 DM的风险呈负相关。

Within 8, 648 participants of our cohort which was built up in 1998, 300 first ever cardiovascular(CVD) events were observed by the end of 2008. Ninety-eight participants were diagnosed to be type 2 diabetes mellitus(T2DM) within the period between the 12th month from baseline and the end of 2008. Habitual consumptions of green tea and milk were associated with decreased risk of total CVD events whereas imbalanced intake of meat and fish, infrequent intake of light-colored vegetables and fruits, and high consumption of rice and grain products were associated with the elevated risk. Low intake of fish and meat was associated with development of T2DM. As for biomarkers measured from stored serum, high-sensitivity CRP was positively associated with the risk of total CVD, ischemic heart disease(IHD) and T2DM ; uric acid was positively associated with the risk of T2DM ; LDL cholesterol was positively associated with and T2DM ; and total bilirubin was negatively associated with the risk of T2DM.