A cohort study on relationship of tea/coffee drinking, dietary and exercise habits with cardiovascular events and diabetes mellitus, and seroepidemiological analyses on the roles of some biomarkers in predicting the risk of these diseases

在我们于1998年建立的队列中的8,648名参与者中，到2008年底观察到了300例首次心血管事件。从基线到2008年底的第12个月期间，98名参与者被诊断为2型糖尿病(T2 DM)。经常饮用绿茶和牛奶与总心血管疾病风险降低相关，而肉类和鱼类摄入不平衡、不经常摄入浅色蔬菜和水果以及大量食用大米和谷物产品与风险增加相关。鱼和肉的摄入量低与T2 DM的发生有关。从储存血清中检测的生物标志物中，高敏C反应蛋白与总心血管疾病、缺血性心脏病和T2 DM的风险正相关，尿酸与T2 DM的风险正相关，低密度脂蛋白与T2 DM的风险正相关，总胆红素与T2 DM的风险负相关。

Within 8, 648 participants of our cohort which was built up in 1998, 300 first ever cardiovascular(CVD) events were observed by the end of 2008. Ninety-eight participants were diagnosed to be type 2 diabetes mellitus(T2DM) within the period between the 12th month from baseline and the end of 2008. Habitual consumptions of green tea and milk were associated with decreased risk of total CVD events whereas imbalanced intake of meat and fish, infrequent intake of light-colored vegetables and fruits, and high consumption of rice and grain products were associated with the elevated risk. Low intake of fish and meat was associated with development of T2DM. As for biomarkers measured from stored serum, high-sensitivity CRP was positively associated with the risk of total CVD, ischemic heart disease(IHD) and T2DM ; uric acid was positively associated with the risk of T2DM ; LDL cholesterol was positively associated with and T2DM ; and total bilirubin was negatively associated with the risk of T2DM.