Tea, coffee, dietary habits, physical activity and risk of cardiovascular disease and diabetes: a population-based cohort study in Japan

茶、咖啡、饮食习惯、体力活动与心血管疾病和糖尿病的风险：日本的一项基于人群的队列研究

• 批准号: 15390195
• 负责人: TANABE Naohito
• 金额: $ 4.74万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390195/
• 关键词: cardiovascular disease; stroke; acute coronary syndrome; diabetes; tea and coffee; dietary habits; physical activity; cohort study; 心筋梗塞; 急性心筋梗塞; 突然死; コーホート研究; 体重; 生活習慣; 疫学; 虚血性心疾患; 危険因子; 発症調査

We assessed the relationships between lifestyle factors and risks of cardiovascular disease and diabetes through a population-based cohort study. Lifestyle factors included tea and coffee consumptions, dietary habits, and physical activity. We observed 74 cerebral infarction, 39 cerebral hemorrhage, 16 subarachnoidal hemorrhage and 26 acute coronary syndrome events from 8,648 subjects during a 5-year follow up from 1998. During the same follow-up period, 101 subjects had also been diagnosed to have diabetes.From the entire cohort, 7752 subjects aged 40-89 were assigned to the statistical analyses, and subjects with a history of the target disease were also excluded from the analysis. Relative risks for total cardiovascular events, cerebral infarction, cerebral hemorrhage, acute coronary syndrome, and diabetes by life style factors were estimated as hazard ratios from Cox proportional hazards models adjusting for sex, age, personal histories of stroke, ischemic heart disease, other heart disease, diabetes, hypertension, hyperlipidemia, and a parental history of the target disease.As the results, green tea consumption was negatively associated with the risks of both types of stroke ; very frequent roasted tea consumption, with the elevated risk of acute coronary syndrome ; consumption of non-green-and-yellow vegetables, negatively with risks of total cardiovascular events and cerebral infarction; fruits consumption, negatively with risks of both types of stroke and diabetes ; imbalanced intake of fish and meet, with elevated risks of cerebral infarction and diabetes ; infrequent intake of fat and oil, with elevated risks of cerebral hemorrhage and acute coronary syndrome. No significant association was found between physical activity levels and risks of concerned diseases.

我们通过一项基于人群的队列研究评估了生活方式因素与心血管疾病和糖尿病风险之间的关系。生活方式因素包括茶和咖啡消费，饮食习惯和体育活动。我们从1998年开始对8,648名受试者进行了为期5年的随访，观察到74例脑梗死、39例脑出血、16例蛛网膜下腔出血和26例急性冠脉综合征事件。在同一随访期间，101名受试者也被诊断为糖尿病，从整个队列中，7752名年龄在40-89岁的受试者被分配到统计分析中，有目标疾病史的受试者也被排除在分析之外。根据考克斯比例风险模型，通过调整性别、年龄、中风、缺血性心脏病、其他心脏病、糖尿病、高血压、高脂血症和父母目标疾病史，估计生活方式因素引起的总心血管事件、脑梗死、脑出血、急性冠脉综合征和糖尿病的相对风险，作为风险比。饮用绿色茶与两种类型的中风风险呈负相关;经常饮用焙炒茶，与急性冠状动脉综合征风险升高;食用非绿色和黄色蔬菜，与总心血管事件和脑梗死风险呈负相关;水果的摄入量与中风和糖尿病的发病率呈负相关;鱼和肉的摄入量不平衡，会增加脑梗塞和糖尿病的发病率;脂肪和油的摄入量不足，会增加脑出血和急性冠状动脉综合征的发病率。体力活动水平与相关疾病的风险之间没有显着关联。