Effect of risk factors and lifestyle behaviors on progression of atherosclerosis and arteriolosclerosis

我们招募了 520 名参与者进行心血管健康检查，并对他们进行了大约 5 年的随访。我们研究了生活方式因素和临床心血管危险因素与动脉硬化（动脉粥样硬化和动脉粥样硬化）变化的关系。我们发现，男性和女性的收缩压升高与多种血管病变的动脉硬化进展相关。此外，脂质功能障碍，特别是低HDL胆固醇水平和血糖异常与男性动脉硬化的进展相关，吸烟与女性动脉硬化的进展相关。这些发现表明，对于日本人来说，预防高血压、血脂异常、血糖异常和吸烟对于预防动脉硬化的进展可能很重要。

We recruited 520 participants in a cardiovascular health checkup and followed up them for around 5 years. We examined the association of lifestyle factors and clinical cardiovascular risk factors in relation to change of arteriosclerosis (atherosclerosis, and arteriolosclerosis). We found that the elevation of systolic blood pressure was associated with progression of arteriosclerosis at several vascular lesions among both men and women. Additionally, lipid dysfunction, especially low HDL-cholesterol level, and glucose abnormality were associated with progression of arteriosclerosis among men, and smoking was associated with progression of arteriosclerosis among women. These findings suggest that the prevention of high blood pressure, lipid dysfunction, glucose abnormality, and smoking may be important to prevent progression of arteriosclerosis for Japanese.