Efficacy of Computer-Assisted Measurements for Retinal Artery and Vein in relation to Risk of Stroke

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Using a quantitative retinal image analysis, we measured the diameter of retinal artery and vein in individuals participated in health screening program in Osaka, Akita, and Ibaraki. Then, we examined the association of these quantitative measures in relation to risk of developing stroke. Retinal arteriolar narrowing was associated with increased risk of stroke; compared with individuals with larger retinal arteriolar diameter, those with smaller retinal arteriolar diameter had 4 to 5-fold higher risk of stroke. This association was partially independent of traditional Scheie’s classification of retinal arteriolosclerosis. The current findings suggest that the predictive ability of the fundus assessment in relation to stroke risk may be improved by using the proposed quantitative retinal vessels in addition to the Scheie’s classification, which is widely used at health checkup in Japan.