The analysis of the predictive marker for the efficacy of the angiogenesis inhibitor for the treatment of hepatocellular carcinoma

(基础)我们研究了26例肝癌组织中血管生成相关或细胞增殖相关基因(共37个基因)的mRNA表达。只有HIF1α的表达与肿瘤的病理分化、肿瘤血管和大体血管侵犯有关。(临床)我们探索了54例肝细胞癌患者索拉非尼治疗效果的预测指标，发现改良的RECIST结果和AFP水平有助于预测索拉非尼治疗的疗效。

(Basic) We explored the mRNA expression of angiogenesis-related or cell proliferation-related genes (total 37 genes) in 26 hepatocarcinoma tissues. Only HIF1α expression was correlated with pathological differentiation, tumor vascularity, and macroscopic vascular invasion. (Clinical)We explored the predictive marker for the treatment efficacy of sorafenib in 54 hepatocellular carcinoma patients and revealed that modified RECIST findings and AFP level were useful for the prediction of the efficacy of the sorafenib treatment.