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Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination

Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination
鉴定有助于心血管发育的新细胞谱系并阐明其命运决定的机制
批准号:
21390238
负责人:
KURIHARA Hiroki
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
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英文摘要
Early endothelin receptor type A expression defines a subdomain of the first heart field contributing to chamber formation, in which endothelin signaling is involved by stimulating ERK phosphorylation and Tbx5 expression. In angiogenesis, complex cell behavior and tip cell overtaking were revealed to contribute to branching morphogenesis by a time-lapse imaging and computer-assisted analysis.
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会议论文
Endothelin type-A receptor expression defines a distinct subpopulation withinthe first heart field contributing to chamber myocardium
内皮素 A 型受体表达定义了第一心野内对心室肌有贡献的独特亚群
DOI: --
发表时间: 2010
期刊: Development
影响因子: 4.6
作者: [Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H]
通讯作者: Kurihara H
Novel roles of the neural crest in coronary artery formation through the Endothelin-1/Endothelin A receptor signaling
神经嵴通过内皮素-1/内皮素 A 受体信号传导在冠状动脉形成中的新作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Weng L, Du J, Zhou J, Ding J, Wakita T, Kohara M, Toyoda T, Kamota T, Nishiyama T, Yuichiro Arima]
通讯作者: Yuichiro Arima
Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway
内皮素1/内皮素A型受体信号通过Dlx5/6独立途径调节咽弓动脉发育
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [片村嘉男, 相方浩, 長沖祐子, 石田友希, 橋本義政, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 高橋祥一, 茶山一彰, 山下潤, 前村浩二, Ki-Sung Kim]
通讯作者: Ki-Sung Kim
Sirt3, a mitochondrial sirtuin, protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
Sirt3 是一种线粒体 Sirtuin,可保护体外受精的小鼠植入前胚胎免受氧化应激诱导的 p53 介导的发育停滞
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Nishiyama T, Kaneda R, Makino S, Fukuda K, Yumiko Kawamura]
通讯作者: Yumiko Kawamura
67
    Characterization of neural crest cells migrating into the heart
    • 批准号:
      26670396
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      KURIHARA Hiroki
    • 依托单位:
    Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction
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      24249047
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $24.54万
    • 财政年份:
      2012
    • 负责人:
      KURIHARA Hiroki
    • 依托单位:
    Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
    • 批准号:
      23659107
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      KURIHARA Hiroki
    • 依托单位:
    Analysis of cardiovascular development and pathophysiology by gene engineering of the endothelin system in mice
    • 批准号:
      18390229
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.36万
    • 财政年份:
      2006
    • 负责人:
      KURIHARA Hiroki
    • 依托单位:
    海外基金