Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination
Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination
批准号:
21390238
负责人:
KURIHARA Hiroki
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
早期A型内皮素受体的表达定义了第一心野参与心腔形成的一个亚域,内皮素信号通过刺激ERK磷酸化和Tbx5的表达而参与其中。在血管生成中,通过时间推移成像和计算机辅助分析发现,复杂的细胞行为和尖端细胞的超越有助于分支形态的发生。
英文摘要
Early endothelin receptor type A expression defines a subdomain of the first heart field contributing to chamber formation, in which endothelin signaling is involved by stimulating ERK phosphorylation and Tbx5 expression. In angiogenesis, complex cell behavior and tip cell overtaking were revealed to contribute to branching morphogenesis by a time-lapse imaging and computer-assisted analysis.
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Involvement of non-coding RNA in the Endotelin signaling in branchial arch development
非编码 RNA 参与鳃弓发育的内皮素信号传导
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yano Y, Inokuchi T, Kario K., Yukiko Kurihara]
通讯作者:
Yukiko Kurihara
Transcriptional regulation of non-coding RNA Evf-2 in the Endothelin-1/Dlx5/Dlx6 pathway
Endothelin-1/Dlx5/Dlx6 通路中非编码 RNA Evf-2 的转录调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Y Matsumoto, 他, Yasunobu Uchijima]
通讯作者:
Yasunobu Uchijima
DOI:
--
发表时间:
2010
期刊:
Cell.Dev.Biol.
影响因子:
--
作者:
[Ago T, et al., Gitton Y]
通讯作者:
Gitton Y
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-I in mice and on facial skin elasticity in humans
局部应用 α-D-葡萄糖基甘油对小鼠真皮胰岛素样生长因子-I 水平和人类面部皮肤弹性的影响
DOI:
--
发表时间:
2010
期刊:
Biosci.Biotechnol.Biochem.
影响因子:
--
作者:
[Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, and Kimura S, Harada N]
通讯作者:
Harada N
Id1 may control the specification and the timing of Notch signaling in vascular endothelial cells during angiogenesis
Id1可能控制血管生成过程中血管内皮细胞Notch信号传导的规范和时间
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shirasaki O, Kuwabara M, Saito M, Tagami K, Washiya S, Kario K, 西山功一]
通讯作者:
西山功一
共 67 条
Characterization of neural crest cells migrating into the heart
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批准号:26670396
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
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负责人:KURIHARA Hiroki
-
依托单位:
Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction
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批准号:24249047
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$24.54万
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财政年份:2012
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负责人:KURIHARA Hiroki
-
依托单位:
Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
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批准号:23659107
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2011
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负责人:KURIHARA Hiroki
-
依托单位:
Analysis of cardiovascular development and pathophysiology by gene engineering of the endothelin system in mice
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批准号:18390229
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.36万
-
财政年份:2006
-
负责人:KURIHARA Hiroki
-
依托单位:
Molecular cascades underlying the integration of cell differentiation and morphogenesis in cranial/cardiac neural crest development
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批准号:16390218
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2004
-
负责人:KURIHARA Hiroki
-
依托单位:
Molecular signaling mechanisms underlying cardiovascular and branchial morphogenesis
-
批准号:14370231
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2002
-
负责人:KURIHARA Hiroki
-
依托单位:
ESTABLISHMENT OF MICE DEFICTENT IN A VASOACTIVE PEPTIDE BY GENE TARGETING AND THEIR APPLICATION TO PATHOPHYSIOLOGICAL ANALYSIS
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批准号:06454286
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.54万
-
财政年份:1994
-
负责人:KURIHARA Hiroki
-
依托单位:
ESTABLISHMENT OF AN ANIMAL MODEL FOR CONGENITAL CRANIOFACIAL DISEASES BY GENE TARGETING AND DEVELOPMENT OF THEIR GENETIC DIAGNOSIS.
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批准号:06557065
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$8.06万
-
财政年份:1994
-
负责人:KURIHARA Hiroki
-
依托单位:
海外基金