Development of nocturnal triggered blood pressure monitor and international research for its clinical application

我们一直在尝试开发血压监测仪，以检测阻塞性睡眠呼吸暂停综合征中睡眠呼吸暂停发作引起的血压波动。到目前为止，我们已经开发了基于it的夜间血压监测系统，该系统利用血氧饱和度下降的信号来检测血压波动，并将数据传输到数据服务器，并自动分析和显示这些数据。通过使用该系统，我们开展了多中心临床研究，旨在揭示血压升高与心血管风险之间的关系。到目前为止，招募的患者超过520人。此外，我们发现夜间服用血管舒张药和交感解药抗高血压药物可显著降低血压飙升。我们还开发了利用低心率信号检测夜间基础血压的算法，并开始了性能验证。

We have been trying to develop the blood pressure monitor which detects blood pressure surges induced by sleep apnea episodes in obstructive sleep apnea syndromes. Until now, we have developed the IT-based nocturnal blood pressure monitoring system which detects blood pressure surges by using the signals of oxygen desaturation falls and transmits the data to the data server and analyze and displays these data automatically. By using this system, we have started multi-center clinical research aimed to reveal the relationship between blood pressure surge and cardiovascular risks. Until now, the number of recruiting patients is over 520. Furthermore, we revealed the nighttime dosing of both vasodilating and sympatholytic antihypertensive drugs is effective to reduce blood pressure surge significantly.And we have also developed the algorithm which detects nocturnal basal blood pressure by using the signals of low heart rate and have started its performance verification.