Development of nocturnal triggered blood pressure monitor and international research for its clinical application

夜间触发式血压计的研制及其临床应用的国际研究

• 批准号: 21390247
• 负责人: KARIO KAZUOMI
• 金额: $ 11.32万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390247/
• 关键词: トリガー血圧計; 家庭血圧計; 睡眠時無呼吸症候群; 夜間低酸素; 夜間高血圧; 基底血圧; スリープサージ; 血圧測定

We have been trying to develop the blood pressure monitor which detects blood pressure surges induced by sleep apnea episodes in obstructive sleep apnea syndromes. Until now, we have developed the IT-based nocturnal blood pressure monitoring system which detects blood pressure surges by using the signals of oxygen desaturation falls and transmits the data to the data server and analyze and displays these data automatically. By using this system, we have started multi-center clinical research aimed to reveal the relationship between blood pressure surge and cardiovascular risks. Until now, the number of recruiting patients is over 520. Furthermore, we revealed the nighttime dosing of both vasodilating and sympatholytic antihypertensive drugs is effective to reduce blood pressure surge significantly.And we have also developed the algorithm which detects nocturnal basal blood pressure by using the signals of low heart rate and have started its performance verification.

我们一直在努力开发的血压监测仪，检测阻塞性睡眠呼吸暂停综合征的睡眠呼吸暂停发作引起的血压波动。到目前为止，我们已经开发了基于信息技术的夜间血压监测系统，该系统利用氧饱和度下降福尔斯信号检测血压波动，并将数据传输到数据服务器，自动分析和显示这些数据。通过使用该系统，我们已经开始了多中心临床研究，旨在揭示血压飙升与心血管风险之间的关系。到目前为止，招募的患者人数超过520人。此外，我们还发现，在夜间服用血管舒张和交感神经阻滞的降压药物可以显著降低血压波动，并且我们还开发了利用低心率信号检测夜间基础血压的算法，并已开始性能验证。

项目成果

Effects of antihypertensive treatment in Asian populations: a meta-ana ysis of prospective randomized controlled studies (CARdiovascular protectioN group in Asia: CARNA).

亚洲人群抗高血压治疗的效果：前瞻性随机对照研究的荟萃分析（亚洲心血管保护组：CARNA）。

• DOI: 10.1016/j.jash.2013.09.002
• 发表时间: 2014
• 期刊: J Am Soc Hypertens.
• 作者: Yano Y;Briasoulis A;Bakris GL;Hoshide S;Wang JG;Shimada K;Kario K.
• 通讯作者: Kario K.

Both chronic kidney disease and nocturnal blood pressure associate with strokes in the elderly.

慢性肾脏病和夜间血压都与老年人中风有关。

• DOI: 10.1159/000354232
• 发表时间: 2013
• 期刊: Am J Nephrol.
• 作者: Yano Y;Bakris GL;Matsushita K;Hoshide S;Shimada K;Kario K.
• 通讯作者: Kario K.

血圧測定装置

血压测量装置

• 发表时间: 2011

Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients

• DOI: 10.1016/j.diabres.2012.09.014
• 发表时间: 2012-12-01
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Eguchi, Kazuo;Hoshide, Satoshi;Kario, Kazuomi
• 通讯作者: Kario, Kazuomi

Prospective Study on Occupational Stress and Risk of Stroke

• DOI: 10.1001/archinternmed.2008.503
• 发表时间: 2009-01-12
• 期刊: ARCHIVES OF INTERNAL MEDICINE
• 作者: Tsutsumi, Akizumi;Kayaba, Kazunori;Ishikawa, Shizukiyo
• 通讯作者: Ishikawa, Shizukiyo