Control of energy metabolism by changes of the organ lipid quality through fatty acid elongase Elovl6.

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Elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated FAs with 12, 14, and 16 carbons. In this research, we generated liver-specific Elovl6 deficient mice (LKO), brain-specific Elovl6 deficient mice (BKO), and Elovl6^<-/-> bone marrow cells-transplanted LDLR^<-/-> mice, and aimed to elucidate the physiological role of Elovl6 in the liver, feeding behavior, and atherosclerosis. High sucrose diet-feeding in LKO mice caused higher insulin sensitivity than those of flox mice. BKO mice showed the change of dietary preference. Aortic atherosclerotic lesion areas were significantly smaller in Elovl6^<-/-> bone marrow cells-transplanted LDLR^<-/-> mice than in wild-type. These results suggest that inhibiting Elovl6 activity may provide a novel therapeutic approach for treating insulin resistance, diabetes, metabolic syndrome, and cardiovascular risks by circumventing obesity problems.