Regulation of cellular cytoskeleton by the soluble LDL receptor family with the application for novel anti-atherosclerosis therapy

可溶性LR11是LDL受体家族的成员，在内膜平滑肌细胞的病理表型转化中起重要作用。本研究的目的是阐明通过LR11介导的途径调节细胞骨架重组以实现加速细胞迁移和粘附的潜在机制，sLR11在各种疾病中的参与，以及开发新的抗动脉粥样硬化疗法的基础意义。从细胞生物学、动物或患者分析获得的结果表明，可溶性LR11对于漂浮细胞以及附着细胞的迁移、脂肪细胞的分化和血管损伤的发展的共同机制是重要的。这些结果表明，针对该分子的靶向调控有助于开发新的治疗方法来调节动脉粥样硬化和其他疾病领域的细胞迁移。

Soluble form of LR11, a member of LDL receptor family, plays an important role in the pathological phenotypic conversion of intimal smooth muscle cells. The aim of study was to clarify the mechanism underlying the regulation of cytoskeleton reorganization to achieve the acceleration of cellular migration and adhesion through the LR11-mediated pathways, the involvement of sLR11 in various diseases, and the basic significance for the development of novel therapy against atherosclerosis. The results obtained from the cell-biological, animal or patient analysis has shown that soluble LR11 is important for the common mechanism underlying the migration for floating cells as well as attached cells, the differentiation of adipocytes, and the development of vascular injury. These results suggested that the target regulation focused on the molecule contributes to the development of novel therapy to regulate the cell migration in the fields of atherosclerosis and also in other diseases.