Regulation of cellular cytoskeleton by the soluble LDL receptor family with the application for novel anti-atherosclerosis therapy

点击翻译按钮获取中文摘要

Soluble form of LR11, a member of LDL receptor family, plays an important role in the pathological phenotypic conversion of intimal smooth muscle cells. The aim of study was to clarify the mechanism underlying the regulation of cytoskeleton reorganization to achieve the acceleration of cellular migration and adhesion through the LR11-mediated pathways, the involvement of sLR11 in various diseases, and the basic significance for the development of novel therapy against atherosclerosis. The results obtained from the cell-biological, animal or patient analysis has shown that soluble LR11 is important for the common mechanism underlying the migration for floating cells as well as attached cells, the differentiation of adipocytes, and the development of vascular injury. These results suggested that the target regulation focused on the molecule contributes to the development of novel therapy to regulate the cell migration in the fields of atherosclerosis and also in other diseases.