Functional analysis of NLRR family genes in neuroblastoma

神经母细胞瘤中NLRR家族基因的功能分析

• 批准号: 21390317
• 负责人: NAKAGAWARA Akira
• 金额: $ 11.4万
• 依托单位: Chiba Cancer Center (Research Institute)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390317/
• 关键词: NLLRR1; NLRR2; NLRR3; Neuroblastoma; 細胞増殖; NLRR1

The novel human NLRR family genes, which were previously cloned from our cDNA project, were functionally analyzed. NLRR1 was found to enhance cell growth to promote progression of neuroblastoma. The knockout mice we generated proved that NLRR1 suppresses the cell growth signals through the function of lipid raft. We have successfully generated anti-NLRR1 monoclonal antibodies which can be developed to be therapeutic use. NLRR2 regulated the cell survival signals through induction of ER stress. NLRR3 induced cellular differentiation and was negatively transcribed by MYCN. Thus, NLRR family molecules were found to share their roles to regulate cell functions and to contribute to the clinical behavior of human neuroblastoma.

以前是从我们的cDNA项目中克隆的新型人NLRR家族基因。发现NLRR1可增强细胞生长，以促进神经母细胞瘤的进展。我们生成的敲除小鼠证明了NLRR1通过脂质筏的功能抑制细胞生长信号。我们成功地产生了可以开发为治疗用途的抗NLRR1单克隆抗体。 NLRR2通过诱导ER应力来调节细胞存活信号。 NLRR3诱导细胞分化，并由MYCN负转录。因此，发现NLRR家族分子具有调节细胞功能的作用，并有助于人类神经母细胞瘤的临床行为。

项目成果

The 6th Asia Cancer Forum : What Should We Do to Place Cancer on the Global Health Agenda? Sharing Information Leads to Human Security

第六届亚洲癌症论坛：我们应该如何将癌症纳入全球健康议程？

• DOI: 10.1093/jjco/hyr036
• 发表时间: 2011
• 期刊: Jpn. J. Clin. Oncol
• 作者: Kawahara N;Sugimura H;Nakagawara A;Masui T;Miyake J;Akiyama M;Wahid IA;Hao X;Akaza H
• 通讯作者: Akaza H

Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma

• DOI: 10.1158/1541-7786.mcr-08-0501
• 发表时间: 2009-12-01
• 期刊: MOLECULAR CANCER RESEARCH
• 影响因子: 5.2
• 作者: Wetterskog, Daniel;Moshiri, Abtin;Funa, Keiko
• 通讯作者: Funa, Keiko

MCL-1V, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair.

MCL-1V，一种新型小鼠抗凋亡 MCL-I 变体，由非规范剪接对的 RNA 剪接产生。

• 发表时间: 2010
• 期刊: Biochem.Biophys.Res.Commun.
• 作者: Kojima S;Nakagawara A;et al.
• 通讯作者: et al.

Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma

• DOI: 10.1111/j.1349-7006.2010.01586.x
• 发表时间: 2010-07-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Iwata, Shintaro;Takenobu, Hisanori;Kamijo, Takehiko
• 通讯作者: Kamijo, Takehiko

Molecular and genetic bases of neuroblastoma

• DOI: 10.1007/s10147-012-0415-7
• 发表时间: 2012-06-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Kamijo, Takehiko;Nakagawara, Akira
• 通讯作者: Nakagawara, Akira