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Functional analysis of NLRR family genes in neuroblastoma

Functional analysis of NLRR family genes in neuroblastoma
神经母细胞瘤中NLRR家族基因的功能分析
批准号：
21390317
负责人：
NAKAGAWARA Akira
金额：
$11.4万
依托单位：
Chiba Cancer Center (Research Institute)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390317/
关键词：
NLLRR1NLRR2NLRR3Neuroblastoma細胞増殖NLRR1

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英文摘要
The novel human NLRR family genes, which were previously cloned from our cDNA project, were functionally analyzed. NLRR1 was found to enhance cell growth to promote progression of neuroblastoma. The knockout mice we generated proved that NLRR1 suppresses the cell growth signals through the function of lipid raft. We have successfully generated anti-NLRR1 monoclonal antibodies which can be developed to be therapeutic use. NLRR2 regulated the cell survival signals through induction of ER stress. NLRR3 induced cellular differentiation and was negatively transcribed by MYCN. Thus, NLRR family molecules were found to share their roles to regulate cell functions and to contribute to the clinical behavior of human neuroblastoma.
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    Generation of the MYCN/NCYM mouse model and the drug discovery for human neuroblastoma
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    • 批准号：
      19390289
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.98万
    • 财政年份：
      2007
    • 负责人：
      NAKAGAWARA Akira
    • 依托单位：
      Chiba Cancer Center (Research Institute)
    Development of personalized medicine and therapeutic strategies for pediatric solid tumors
    • 批准号：
      17015046
    • 项目类别：
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额：
      $42.75万
    • 财政年份：
      2005
    • 负责人：
      NAKAGAWARA Akira
    • 依托单位：
      Chiba Cancer Center (Research Institute)
    Identification of Cancer Stem Cells and Its Clinical Application for Treating Aggressive Neuroblastomas
    • 批准号：
      17390473
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.92万
    • 财政年份：
      2005
    • 负责人：
      NAKAGAWARA Akira
    • 依托单位：
      Chiba Cancer Center Research Institute