Role of signal transduction pathway of Bcl-3 and IkBNA in the pathogenesis of psoriasis

点击翻译按钮获取中文摘要

In order to clarify the role of NF-kB in the pathogenesis of psoriasis, we examined whether pathological change of psoriasis was induced in IkBNS deficient mice. We also clarified the function of Bcl-3 in cultured epidermal keratinocytes. Although the IkBNS deficient mice did not spontaneously generate psoriatic skin phenotype, the psoriasis pathological change was induced by the wound stimulus and the TPA treatment. IL-22-induced psoriasis-related genes were suppressed by the pretreatment of Bcl-3 suppression. On the other hand, overexpression of Bcl-3 induced psoriasis-related gene expression. Furthermore, Bcl-3 was strongly detected psoriatic skin. In conclusion, NFkB and Bcl-3 play important roles in the pathogenesis of psoriasis.