Development of novel CT contrast agents with long retention in the vessel

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The aim of this study is to develop novel CT contrast agent with a longer retention in blood in order to visualize vascular structure in a target tissue or angiogenesis of tumor. For this purpose, we use iodine or gold as a contrast element and human serum albumin or dendrimer modified with PEG as a carrier compound. Iodine modified agent showed a less enhancement effect in vivo because of its instability in blood. Gold modified agent showed a longer enhancement effect in vivo in comparison with a commercially available iodine contrast agent.