Novel therapy for aortic aneurysms by targeting a mechanical stress sensor

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Abdominal aortic aneurysm(AAA) is characterized by chronic inflammation. Although a mechanical stress may contribute to pathogenesis of AAA, the mechanism that connects mechanical stress to inflammation is not yet understood. In this study, we demonstrated that the mechanical stress caused the activation of inflammatory signaling molecule and the release of inflammatory cytokine in macrophages. In addition, our data suggested that ASC might be critical for the linkage between mechanical stress and inflammatory response.