Development of an innovative drug targeting th e ileal mucosa to promote intestinal adaptation and to treat pouchitis

药物递送系统是指能够有效地将药物带入靶组织或细胞，从而达到最大的治疗效果和最小的副作用。聚乳酸/乙醇酸是无害的，可作为药物载体使用。我们建立了评价PLGA药物颗粒分布、药物释放以及药物对靶细胞和非靶细胞影响的方法。由于口服PLGA颗粒不能被胃肠道粘膜吸收，因此可能需要对颗粒表面进行修饰。

Drug delivery system is defined as the method which enables to efficiently bring drugs to target tissues or cells, resulting in therapeutic effects at most and side effects at least. Poly lactic/glycolic acids are harmless and available as a drug carrier. We established the methods to evaluate distribution of drug-incorporated PLGA particles, release of drugs, and effects of drugs on target and non-target cells. Because oral administration of PLGA particles failed to be absorbed in GI mucosa, modif ication of the particle surface may be required.