Development of an innovative drug targeting th e ileal mucosa to promote intestinal adaptation and to treat pouchitis

给药系统是指能够有效地将药物输送到靶组织或细胞中，从而达到最大疗效和最小副作用的方法。聚乳酸/乙醇酸是无害的，可用作药物载体。我们建立了评价药物包埋的PLGA颗粒的分布、药物释放以及药物对靶细胞和非靶细胞的作用的方法。由于口服PLGA颗粒不能在GI粘膜中吸收，因此可能需要颗粒表面的澄清。

Drug delivery system is defined as the method which enables to efficiently bring drugs to target tissues or cells, resulting in therapeutic effects at most and side effects at least. Poly lactic/glycolic acids are harmless and available as a drug carrier. We established the methods to evaluate distribution of drug-incorporated PLGA particles, release of drugs, and effects of drugs on target and non-target cells. Because oral administration of PLGA particles failed to be absorbed in GI mucosa, modif ication of the particle surface may be required.