Development of an artificial intestinal mucosa

我们试图利用微型机电系统(MEMS)来构建由绒毛和隐窝样结构组成的人工肠粘膜，这些系统被用来创建三维微结构。我们成功地制作了表面具有多个突起的“小肠”状结构和具有多个中空的“结肠”状结构。在结构和培养的上皮细胞上用人工膜覆盖不规则表面。我们可以通过发明一种新的系统来产生人造粘膜，这种系统能够在上皮细胞和基底膜下的细胞之间进行分子交换。

We tried to construct"artificial intestinal mucosa", which is composed of villus-and crypt-like structures, using micro electric mechanical systems (MEMS), which are utilized for creating 3-demensional micro-constructs. We successfully made"small intestine"-like structures featured by multiple projections on the surface and"colon"-like structures with multiple hollows. We covered the irregular surface with the artificial membrane on the structures and cultured epithelial cells. We might generate an artificial mucosa by inventing a new system enabling exchange of molecules between epithelial cells and cells under basal membrane.