Study of the correlation between disseminated cancer cells and host factors in establishment of recurrence and metastasis of hepatocellular carcinoma

播散性癌细胞与宿主因素在肝细胞癌复发转移中的相关性研究

基本信息

批准号：
21390369
负责人：
KAMIYAMA Toshiya
金额：
$ 11.4万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390369/
关键词：
遊離癌細胞癌幹細胞 CD133 肝細胞癌大腸癌 AFPmRNA VEGFR1mRNA

项目摘要

Cytoplasmic expression of CD133 in HCC is associated with elevated serum AFP level, histologically high-grade tumor, and tumor invasion to the major branch of the portal vein. Positive cytoplasmic expression of CD133 represented the risk of poor prognosis. CD133 overexpression was an independent prognostic factor for PS of colorectal cancer (CRC) patients. Evaluation of the frequency and pattern of CD133 expression is useful for predicting prognosis, recurrence, and chemosensitivity in CRC patients. We found a significant tendency for patients who were positive for BM-AFP mRNA to experience recurrence within 1 year after surgery compared to those negative for BM-AFP mRNA. The BM-VEGFR-1 mRNA level of all HCC patients was higher than that of normal controls and the PH-VEGFR-1 mRNA level of almost all patients was higher that of normal controls. The classification by BM-VEGFR-1 mRNA/BM-AFP mRNA was a significant risk factor for recurrence within 1 year after surgery. The importance of the coexistence of disseminated cancer cells and VEGFR-1-positive hematopoietic bone marrow progenitor cells was also proved because the DFS curve of patients negative for BM-AFP mRNA and BM-VEGFR-1 mRNA ; low was better in the other 3 groups. The evaluation of BM-AFP and BM-VEGFR-1 mRNA in patients with HCC may be a valuable predictor of disease recurrence following curative resection.

HCC中CD133的细胞质表达与血清AFP水平升高，组织学高度肿瘤以及对门静脉主要分支的肿瘤侵袭有关。 CD133的阳性细胞质表达代表了预后不良的风险。 CD133过表达是大肠癌（CRC）患者PS的独立预后因素。评估CD133表达的频率和模式可用于预测CRC患者的预后，复发和化学敏感性。我们发现，与BM-AFP mRNA的阴性相比，在手术后1年内对BM-AFP mRNA呈阳性的患者存在很大的趋势。所有HCC患者的BM-VEGFR-1 mRNA水平高于正常对照组的BM-VEGFR-1 mRNA，几乎所有患者的pH-VEGFR-1 mRNA水平都高于正常对照。 BM-VEGFR-1 mRNA/BM-AFP mRNA分类是手术后1年内复发的重要危险因素。由于BM-AFP mRNA和BM-VEGFR-1 mRNA阴性的DFS曲线阴性，也证明了传播癌细胞和VEGFR-1阳性造血骨髓祖细胞的共存的重要性。在其他三个组中，低点更好。 HCC患者中BM-AFP和BM-VEGFR-1 mRNA的评估可能是治愈切除后疾病复发的宝贵预测指标。